Michael Schonfeld, Janice Averilla, Sumedha Gunewardena, Steven A. Weinman, Irina Tikhanovich – 24 April 2022 – Alcohol‐associated liver disease is a major cause of alcohol‐related mortality. However, the mechanisms underlying disease progression are not fully understood. Recently we found that liver molecular pathways are altered by alcohol consumption differently in males and females. We were able to associate these sex‐specific pathways with two upstream regulators: H3K4‐specific demethylase enzymes KDM5B and KDM5C.

Sarah Wang, Ana Teresa Limon‐Miro, Christofer Cruz, Puneeta Tandon – 23 April 2022

Sarah Wang, Ana Teresa Limon‐Miro, Christofer Cruz, Puneeta Tandon – 23 April 2022

23 April 2022

Aparna Goel, Allison Kwong – 23 April 2022

Aparna Goel, Allison Kwong – 23 April 2022

Alcohol-associated liver disease (ALD) represents a spectrum of liver injury resulting from alcohol use, ranging from hepatic steatosis to more advanced forms including alcoholic hepatitis (AH), alcohol-associated cirrhosis (AC), and acute AH presenting as acute-on-chronic liver failure.

Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez – 22 April 2022

Histological assessment of the liver, and thus, liver biopsy, is a cornerstone in the evaluation and management of patients with liver disease and has long been considered to be an integral component of the clinician’s diagnostic armamentarium.

The advent of safe, well-tolerated, and highly efficacious (>95% cure rate) direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) infection has ushered in an era in which elimination of hepatitis C is conceivable.