Viral features of lamivudine resistant hepatitis B genotypes A and D

Bernhard Zöllner, Jörg Petersen, Elisabeth Puchhammer‐Stöckl, Josef Kletzmayr, Martina Sterneck, Lutz Fischer, Matthias Schröter, Rainer Laufs, Heinz‐Hubert Feucht – 5 January 2004 – Viral differences among lamivudine resistant hepatitis B (HBV) genotypes have not been yet investigated. Therefore, we analyzed the characteristics of these viral strains in vivo. Forty‐one patients carrying lamivudine resistant HBV were enrolled. Twenty‐six patients (63%) carried resistant HBV genotype A (group A) and 15 patients (37%) carried resistant HBV genotype D (group D).

Reversal of liver fibrosis in aryl hydrocarbon receptor null mice by dietary vitamin A depletion

Fausto Andreola, Diego F. Calvisi, Guillermo Elizondo, Sonia B. Jakowlew, Jennifer Mariano, Frank J. Gonzalez, Luigi M. De Luca – 5 January 2004 – Aryl hydrocarbon receptor (AHR)‐null mice display a liver fibrosis phenotype that is associated with a concomitant increase in liver retinoid concentration, tissue transglutaminase type II (TGaseII) activity, transforming growth factorβ (TGFβ) overexpression, and accumulation of collagen.

Prevalence and predictors of esophageal varices in patients with primary sclerosing cholangitis

Claudia O. Zein, Keith D. Lindor, Paul Angulo – 5 January 2004 – Patients with primary sclerosing cholangitis (PSC) may develop and bleed from esophageal varices. However, the exact prevalence of esophageal varices in patients with PSC remains unknown and potential predictors of esophageal varices in this population have not been identified. Our aim was to determine the prevalence of esophageal varices in patients with PSC and the variables that predict their presence.

Oxidative stress as a trigger for cellular immune responses in patients with alcoholic liver disease

Stephen F. Stewart, Matteo Vidali, Christopher P. Day, Emanuele Albano, David E.J. Jones – 5 January 2004 – Serum antibodies reactive with neo‐antigens generated during ethanol metabolism have been identified in patients with alcoholic liver disease (ALD), although their role in the pathogenesis of disease remains unclear.

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