Syndromic incidence of ovarian cancer after liver transplantation: Is breast cancer an antecedent risk?

Joseph F. Buell, E. Steve Woodle – 6 January 2004 – Ovarian cancer is the gynecologic malignancy with the highest number of deaths in the United States. Previous studies had found a decreased incidence of female gynecological malignancies after liver transplantation. In order to estimate the incidence of ovarian carcinoma after liver transplantation, we evaluated 1,708 consecutive liver transplant recipients from 1984 to 2001. Of them, 770 (43%) were female. Routine follow‐ups were performed at 1, 2, 5, and 10 years after transplantation. There were two cases of ovarian carcinoma.

Impact of pretransplant diagnosis of hepatocellular carcinoma on cadveric liver allocation in the era of MELD

Paul H. Hayashi, James F. Trotter, Lisa Forman, Marcelo Kugelmas, Tracy Steinberg, Paul Russ, Michael Wachs, Thomas Bak, Igal Kam, Gregory T. Everson – 6 January 2004 – The allocation system based on the Model for End‐stage Liver Disease (MELD) has led to more patients diagnosed with hepatocellular carcinoma (HCC) being transplanted. We hypothesized that more patients misdiagnosed with HCC are also being transplanted, leading to inappropriate organ allocation.

Harvesting the middle hepatic vein with a right hepatectomy does not increase the risk for the donor

Olivier Scatton, Jacques Belghiti, Federica Dondero, Diane Goere, Daniele Sommacale, Marylène Plasse, Alain Sauvanet, Olivier Farges, Valérie Vilgrain, Francois Durand – 6 January 2004 – The harvesting of the middle hepatic vein (MHV) with a right hepatectomy for living‐donor liver transplantation allows an optimal venous drainage for the recipient but can also have adverse effects for the donor.

Treatment of refractory cholestatic pruritus after liver transplantation with albumin dialysis

Romuald Bellmann, Ivo W. Graziadei, Clemens Feistritzer, Hubert Schwaighofer, Frans Stellaard, Ekkehard Sturm, Christian J. Wiedermann, Michael Joannidis – 6 January 2004 – Albumin dialysis has been shown to improve the outcome in patients with cholestatic liver failure caused by chronic liver disease. This study reports 7 liver transplant recipients who were treated with albumin dialysis for intractable pruritus of different origin (ductopenic graft rejection, non‐anastomotic strictures, and recurrence of hepatitis C).

Results of the first year of the new liver allocation plan

Richard B. Freeman, Russell H. Wiesner, Erick Edwards, Ann Harper, Robert Merion, Robert Wolfe – 6 January 2004 – Liver allocation policy in the U.S. was recently changed to a continuous disease severity scale with minimal weight given to time waiting in an effort to better prioritize deceased donor liver transplant candidates. We compared rates of waiting list registrations, removals, transplants, and deaths during the year prior to implementation of the new liver allocation policy (2/27/01–2/26/02, Era 1) with the first year's experience (2/27/02–2/26/03, Era 2) under this new policy.

Liver transplantation for hepatocellular carcinoma: The MELD impact

Pratima Sharma, Vijayan Balan, Jose L. Hernandez, Ann M. Harper, Erick B. Edwards, Hector Rodriguez‐Luna, Thomas Byrne, Hugo E. Vargas, David Mulligan, Jorge Rakela, Russell H. Wiesner – 6 January 2004 – The new allocation policy of the United Network of Organ Sharing (UNOS) based on the model for end‐stage liver disease (MELD) gives candidates with stage T1 or stage T2 hepatocellular carcinoma (HCC) a priority MELD score beyond their degree of hepatic decompensation.

Native liver xanthogranulomatous cholangiopathy in primary sclerosing cholangitis: Impact on posttransplant outcome

Andrew Paul Keaveny, Fredric David Gordon, Atoussa Goldar‐Najafi, William David Lewis, Elizabeth Anne Pomfret, James John Pomposelli, Roger Lewin Jenkins, Urmila Khettry – 6 January 2004 – A retrospective analysis of 51 primary sclerosing cholangitis (PSC) patients who underwent liver transplant (LT) identified 16 with xanthogranulomatous cholangiopathy (XGC) at the native liver hilum. Pre‐LT clinical and laboratory data and post‐LT course and outcome of patients with XGC were compared with the 35 PSC patients without XGC.

Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver

Elisabetta Bugianesi, Paola Manzini, Sergio D'Antico, Ester Vanni, Filomena Longo, Nicola Leone, Paola Massarenti, Antonio Piga, Giulio Marchesini, Mario Rizzetto – 5 January 2004 – The mechanism(s) determining the progression from fatty liver to steatohepatitis is currently unknown. Our goal was to define the relative impact of iron overload, genetic mutations of HFE, and insulin resistance on the severity of liver fibrosis in a population of subjects with nonalcoholic fatty liver disease (NAFLD) who had low prevalence of obesity and no overt symptoms of diabetes.

Subscribe to