Gennaro Nuzzo, Felice Giuliante, Maria Vellone, Germano De Cosmo, Francesco Ardito, Marino Murazio, Fabrizio D'Acapito, Ivo Giovannini – 30 January 2004 – Hepatic pedicle clamping (HPC) is widely used to control intraoperative bleeding during hepatectomy; intermittent HPC is better tolerated but is associated with blood loss during each period of reperfusion. Recently, it has been shown that ischemic preconditioning (IP) reduces the ischemia‐reperfusion damage for up to 30 minutes of continuous clamping in healthy liver.

Michael A.E. Ramsay, Henry B. Randall, Elizabeth C. Burton – 30 January 2004 – This case report describes a patient who underwent orthotopic liver transplantation and developed extensive hyperacute venous and arterial intravascular thromboses and thromboemboli intraoperatively. The patient was receiving antifibrinolytic therapy with aprotinin. The safety of routine aprotinin therapy in liver transplantation is examined. The value of the thrombelastograph (TEG) as a qualitative assessment of the coagulation system is emphasized. (Liver Transpl 2004;10:310–314.)

Sundararajah Thevananther, Hongdan Sun, Duo Li, Vijaya Arjunan, Samir S. Awad, Samuel Wyllie, Tracy L. Zimmerman, John A. Goss, Saul J. Karpen – 30 January 2004 – Partial hepatectomy leads to an orchestrated regenerative response, activating a cascade of cell signaling events necessary for cell cycle progression and proliferation of hepatocytes. However, the identity of the humoral factors that trigger the activation of these pathways in the concerted regenerative response in hepatocytes remains elusive.

Shiqi Yang, Ayman Koteish, Huizhi Lin, Jiawen Huang, Tania Roskams, Valina Dawson, Anna Mae Diehl – 30 January 2004 – Hepatic steatosis may have a generally benign prognosis, either because most hepatocytes are not significantly injured or mechanisms to replace damaged hepatocytes are induced.

Jose C. FernÁndez‐Checa, Carmen Garcia‐Ruiz – 30 January 2004

Jordi Blanch, Barbara Sureda, Montse Flaviá, Victoria Marcos, Joan de Pablo, Elisa De Lazzari, Antoni Rimola, Victor Vargas, Victor Navarro, Carlos Margarit, Josep Visa – 30 January 2004 – Although the survival rate of patients undergoing orthotopic liver transplantation (OLT) is highly satisfactory, one of the most important objectives for liver transplantation teams at the present time is to achieve the best possible quality of life and psychosocial functioning for these patients after transplantation.

Elisabetta Cerutti, Chiara Stratta, Renato Romagnoli, Maria Maddalena Schellino, Stefano Skurzak, Mario Rizzetto, Giacomo Tamponi, Mauro Salizzoni – 30 January 2004 – Living donor liver transplantation (LDLT) is becoming a widespread procedure. However, the risk of surgical and medical complications in healthy donors is still a major concern. Hypercoagulability contributes to thromboembolic complications after surgery, but alterations of hemostasis after liver resection are difficult to predict.

Thomas D. Boyer – 30 January 2004

Jose M. Estrela, Angel L. Ortega, Julian Carretero – 30 January 2004

Shan Zeng, Nikki Feirt, Michael Goldstein, James Guarrera, Nikalesh Ippagunta, Udeme Ekong, Hao Dun, Yan Lu, Wu Qu, Ann Marie Schmidt, Jean C. Emond – 30 January 2004 – Hepatic ischemia/reperfusion (I/R) injury associated with liver transplantation and hepatic resection is characterized by hepatocellular damage and a deleterious inflammatory response. In this study, we examined whether receptor for advanced glycation end product (RAGE) activation is linked to mechanisms accentuating inflammation on I/R in a murine model of total hepatic ischemia.