Timothy M. Pawlik, Keith A. Delman, Jean‐Nicolas Vauthey, David M. Nagorney, Irene Oi‐Lin Ng, Iwao Ikai, Yoshio Yamaoka, Jacques Belghiti, Gregory Y. Lauwers, Ronnie T. Poon, Eddie K. Abdalla – 25 August 2005 – Vascular invasion and high histologic grade predict poor outcome after surgical resection or liver transplantation for hepatocellular carcinoma (HCC). Despite the known association between tumor size and vascular invasion, a proportion of patients with large tumors can be treated surgically with excellent outcomes.

Loukas Argyriou, Robert Pfitzmann, Lars‐Erik Wehner, Stefan Twelkemeyer, Peter Neuhaus, Karim Nayernia, Wolfgang Engel – 25 August 2005 – Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominantly inherited disorder characterized by cutaneous and mucosal telangiectasias, epistaxis and arteriovenous malformations in lung, liver, central nervous system, and gastrointestinal tract. Mutations in the genes for endoglin (ENG) and for activin A receptor type II‐like kinase 1 (ALK‐1) have been identified to be associated with HHT.

Michael J. Krowka – 25 August 2005

A. Obaid Shakil – 25 August 2005

Valentina Medici, Vincenzo G. Mirante, Luigi R. Fassati, Maurizio Pompili, Domenico Forti, Massimo Del Gaudio, Carlo P. Trevisan, Umberto Cillo, Giacomo C. Sturniolo, Stefano Fagiuoli – 25 August 2005 – A retrospective data analysis on liver transplantation for Wilson's disease (WD) was performed among Italian Liver Transplant Centers. Thirty‐seven cases were identified. The main indication for liver transplantation was chronic advanced liver disease in 78% of patients. Mixed hepatic and neuropsychiatric symptoms were recorded in 32.3%.

Laura M. Kulik, Mary F. Mulcahy, Russell D. Hunter, Albert A. Nemcek, Michael M. Abecassis, Riad Salem – 25 August 2005 – Prior to therapy, model for end stage liver disease (MELD) scoring, diagnostic imaging and tumor staging were performed in a patient with T3 HCC. The patient received an orthotopic liver transplant (OLT) 42 days after treatment. The explant specimen showed complete necrosis of the target tumor. Follow‐up of this patient has demonstrated no evidence of recurrence. There was no life threatening or fatal adverse experiences related to treatment.

Oreste Perrella, Costanza Sbreglia, Alessandro Perrella, Oreste Cuomo, Marco Perrella – 25 August 2005

Eric M. Yoshida, Paul J. Marotta, Paul D. Greig, Norman M. Kneteman, Denis Marleau, Marcelo Cantarovich, Kevork M. Peltekian, Leslie B. Lilly, Charles H. Scudamore, Vincent G. Bain, William J. Wall, Andre Roy, Robert F. Balshaw, Jeffrey S.T. Barkun – 25 August 2005 – Posttransplant chronic renal failure, secondary to calcineurin inhibitor agents, is emerging as a major problem in liver transplantation.

Dieter C. Broering, Jessica Walter, Atef F. Bassas – 25 August 2005 – The main drawback of auxiliary partial orthotopic liver transplantation (APOLT) is the competition of the portal flow between the graft and the native liver, leading to graft failure. In two patients with Crigler‐Najjar syndrome type I, the intrahepatic resistance of the native liver was increased by occluding the recipients middle hepatic vein during parenchymal transection, leading the portal flow towards the graft. This new surgical technique could encourage centers to recommence APOLT.

Hsin‐You Ou, Tung‐Liang Huang, Tai‐Yi Chen, Leo Leung‐Chit Tsang, Allan M. Concejero, Chao‐Long Chen, Yu‐Fan Cheng – 25 August 2005 – Splenic vein thrombosis with gastric variceal bleeding is difficult to manage, and splenectomy may be necessary to stop variceal bleeding. The authors report the case of a post–orthotopic liver transplant patient with bleeding gastric varices secondary to splenic vein thrombosis treated by partial splenic artery embolization.