Narci Teoh, Jacqueline Field, Jaim Sutton, Geoffrey Farrell – 30 January 2004 – Although hepatic ischemia‐reperfusion (IR) injury is partially mediated by tumor necrosis factor‐α (TNF), we recently found that low‐dose TNF before IR is hepatoprotective. We examined the seemingly conflicting roles of TNF in mediating liver injury in a partial hepatic IR model using TNF gene knockout (TNF ko) mice to allow TNF replacement at specified times.

Myron Schwartz – 30 January 2004 – The preferred therapy for hepatocellular carcinoma (HCC) apparently confined to the liver is surgical removal of the tumor. If the location of the tumor and the functional status of the liver are such that resection with an adequate margin can be achieved with low likelihood of subsequent hepatic failure, liver resection is the preferred approach.

Ronnie Tung‐Ping Poon, Sheung‐Tat Fan – 30 January 2004 – Hepatic resection and liver transplantation are considered the only curative treatments for hepatocellular carcinoma (HCC). Liver transplantation for HCCs ≤ 5 cm in diameter has been shown to produce favorable survival results, but its application is limited by the lack of donors. Hepatic resection remains the treatment of choice for patients who are not transplantation candidates because of large tumor, macroscopic vascular invasion, or advanced age.

Massimo Colombo, Angelo Sangiovanni – 30 January 2004

Pierre‐Michel Huet, Gilles Pomier‐Layrargues – 30 January 2004

Jean‐Michel Pawlotsky, John G. McHutchison – 30 January 2004

Masayoshi Horimoto, Péter Fülöp, Zoltán Derdák, Jack R. Wands, György Baffy – 30 January 2004 – The control of liver regeneration remains elusive. Because reactive oxygen species (ROS) are able to mediate cell growth arrest and activate proteins that inhibit the cell cycle, ROS production may have a negative impact on liver regeneration. We examined how liver regeneration is affected by uncoupling protein‐2 (UCP2), an inner mitochondrial membrane carrier that senses and negatively regulates superoxide production.

Dympna M. Kelly, A. Jake Demetris, John J. Fung, Amadeo Marcos, Yue Zhu, Vladimir Subbotin, Lu Yin, Eishi Totsuka, Tomohiro Ishii, Ming C. Lee, Jorge Gutierrez, Guilherme Costa, Raman Venkataraman, Juan R. Madariaga – 30 January 2004 – Increasing shortage of cadaveric grafts demands the utilization of living donor and split liver grafts. The purpose of this study was to 1) define the “small‐for‐size” graft in a pig liver transplant model 2) evaluate pathological changes associated with small‐for‐size liver transplantation.

Michael G. Hughes, Christine K. Rudy, Tae W. Chong, Robert L. Smith, Heather L. Evans, Julia C. Iezzoni, Robert G. Sawyer, Timothy L. Pruett – 30 January 2004 – It is unknown whether all hepatitis C virus (HCV) quasispecies variants found within patient serum have equal capacity to associate with the liver after transplantation; however, in vitro models of HCV infection suggest that variations in the hypervariable region 1 (HVR1) of the second envelope protein (E2) may be important in infectivity.

Masao Omata, Haruhiko Yoshida – 30 January 2004 – Viral hepatitis, by either hepatitis C virus (HCV) or hepatitis B virus (HBV), is the dominant cause of hepatocellular carcinoma (HCC). This is to say that HCC may be prevented by controlling viral infection. Horizontal transmission of HCV has become obsolete owing to the discovery of the virus. Vertical transmission of HBV during delivery has been effectively prevented by vaccination and immunization of neonates. The efficacy of interferon therapy against HCV was recently much improved.