Qing‐gao Deng, Hongyun She, Jason H. Cheng, Samuel W. French, Dennis R. Koop, Shigang Xiong, Hidekazu Tsukamoto – 20 September 2005 – Nonalcoholic steatohepatitis is prevalent among obese individuals with excessive caloric intake, insulin resistance, and type II diabetes. However, no animal models exist that recapitulate this important association. This study produced and characterized steatohepatitis (SH) caused by intragastric overfeeding in mice.

J. Donald Ostrow, Claudio Tiribelli – 20 September 2005

Alan S. Perelson, Eva Herrmann, Florence Micol, Stefan Zeuzem – 20 September 2005 – Viral kinetic modeling has played an important role in the analysis of HCV RNA decay after the initiation of antiviral therapy. Models have provided a means of evaluating the antiviral effectiveness of therapy, of estimating parameters such as the rate of virion clearance and the rate of clearance of hepatitis C virus (HCV)–infected cells, and they have suggested mechanisms of action for both interferon and ribavirin.

Jay H. Hoofnagle – 20 September 2005

Robert F. Schwabe, Soeren V. Siegmund – 20 September 2005

Robert F. Schwabe – 20 September 2005 – Endogenous cannabinoids acting at CB1 receptors stimulate appetite, and CB1 antagonists show promise in the treatment of obesity. CB1−/− mice are resistant to diet‐induced obesity even though their caloric intake is similar to that of wild‐type mice, suggesting that endocannabinoids also regulate fat metabolism. Here, we investigated the possible role of endocannabinoids in the regulation of hepatic lipogenesis.

David McPherson – 20 September 2005

Xin Maggie Wang, Denise Ming Tse Yu, Geoffrey W. McCaughan, Mark D. Gorrell – 20 September 2005 – Injury and repair in chronic liver disease involve cell adhesion, migration, apoptosis, proliferation, and a wound healing response. In liver, fibroblast activation protein (FAP) has both collagenase and dipeptidyl peptidase IV (DPIV) activities and is expressed only by activated hepatic stellate cells (HSC) and myofibroblasts, which produce and degrade extracellular matrix (ECM). FAP was colocalized with collagen fibers, fibronectin, and collagen type I in human liver.

Ting Zhang, Rong‐Tuan Lin, Yuan Li, Steven D. Douglas, Catherine Maxcey, Chun Ho, Jian‐Ping Lai, Yan‐Jian Wang, Qi Wan, Wen‐Zhe Ho – 20 September 2005 – The chronicity of hepatitis C virus (HCV) infection raises the question of how HCV is able to persist in hepatic cells. We show that human primary hepatocytes and human hepatic cell lines (Huh7 and HepG2) spontaneously produce interferon (IFN)‐α that is inhibited in the HCV replicon cells (Huh.8 and FCA‐1).

Hans Christian Spangenberg, Sergei Viazov, Nadine Kersting, Christoph Neumann‐Haefelin, Denise McKinney, Michael Roggendorf, Fritz von Weizsäcker, Hubert E. Blum, Robert Thimme – 20 September 2005 – The precise mechanisms responsible for the failure of intrahepatic hepatitis C virus (HCV)‐specific CD8+ T cells to control the virus during persistent infection have not been fully defined. We therefore studied the CD8+ T‐cell response in 27 HLA‐A2–positive patients using four previously well‐defined HLA‐A2–restricted HCV epitopes.