Masayoshi Horimoto, Péter Fülöp, Zoltán Derdák, Jack R. Wands, György Baffy – 30 January 2004 – The control of liver regeneration remains elusive. Because reactive oxygen species (ROS) are able to mediate cell growth arrest and activate proteins that inhibit the cell cycle, ROS production may have a negative impact on liver regeneration. We examined how liver regeneration is affected by uncoupling protein‐2 (UCP2), an inner mitochondrial membrane carrier that senses and negatively regulates superoxide production.

Jean‐Michel Pawlotsky, John G. McHutchison – 30 January 2004

Pierre‐Michel Huet, Gilles Pomier‐Layrargues – 30 January 2004

Massimo Colombo, Angelo Sangiovanni – 30 January 2004

Ronnie Tung‐Ping Poon, Sheung‐Tat Fan – 30 January 2004 – Hepatic resection and liver transplantation are considered the only curative treatments for hepatocellular carcinoma (HCC). Liver transplantation for HCCs ≤ 5 cm in diameter has been shown to produce favorable survival results, but its application is limited by the lack of donors. Hepatic resection remains the treatment of choice for patients who are not transplantation candidates because of large tumor, macroscopic vascular invasion, or advanced age.

Myron Schwartz – 30 January 2004 – The preferred therapy for hepatocellular carcinoma (HCC) apparently confined to the liver is surgical removal of the tumor. If the location of the tumor and the functional status of the liver are such that resection with an adequate margin can be achieved with low likelihood of subsequent hepatic failure, liver resection is the preferred approach.

Narci Teoh, Jacqueline Field, Jaim Sutton, Geoffrey Farrell – 30 January 2004 – Although hepatic ischemia‐reperfusion (IR) injury is partially mediated by tumor necrosis factor‐α (TNF), we recently found that low‐dose TNF before IR is hepatoprotective. We examined the seemingly conflicting roles of TNF in mediating liver injury in a partial hepatic IR model using TNF gene knockout (TNF ko) mice to allow TNF replacement at specified times.

Minoru Ogawa, Hirofumi Yamamoto, Hiroaki Nagano, Yasuhiro Miyake, Yurika Sugita, Taishi Hata, Byung‐no Kim, Chew Yee Ngan, Bazarragchaa Damdinsuren, Masakazu Ikenaga, Masataka Ikeda, Masayuki Ohue, Shoji Nakamori, Mitsugu Sekimoto, Masato Sakon, Nariaki Matsuura, Morito Monden – 30 January 2004 – We examined the RNA content of the gene encoding angiopoietin (Ang)‐2, a modifier of angiogenesis, in hepatic metastases of colorectal cancer (CRC) to explore the role of this protein in neovascularization of metastatic foci.

Roberto J. Groszmann, Suchat Wongcharatrawee – 30 January 2004

Adrian Reuben – 30 January 2004