Debbie L. Shawcross, Nathan A. Davies, Rajeshwar P. Mookerjee, Peter C. Hayes, Roger Williams, Alistair Lee, Rajiv Jalan – 30 January 2004 – There is increasing evidence that terlipressin is useful in patients with cirrhosis and hepatorenal syndrome, but there are no data of its use in patients with acute liver failure (ALF) in whom hepatorenal syndrome is common. Although terlipressin produces systemic vasoconstriction, it produces cerebral vasodilatation and may increase cerebral blood flow (CBF). Increased CBF contributes to intracranial hypertension in patients with ALF.

Masashi Yoneda, Takenao Hasegawa, Kimihide Nakamura, Masasya Tamano, Toru Kono, Akira Terano – 30 January 2004

Pietro Vajro, Claudia Mandato, Adriana Franzese, Stefania Lucariello – 30 January 2004

Chloe C. McAlister, Zu‐hua Gao, Vivian C. McAlister, Rekha Gupta, James R. Wright, Allan S. MacDonald, Kevork Peltekian – 30 January 2004 – The mechanism by which a liver transplantation might protect a simultaneous kidney transplant in a crossmatch‐positive recipient is unknown. Flow cytometry crossmatch (FCXM) has increased the sensitivity of donor‐specific antibody (DSA) detection compared with complement‐dependant cytotoxicity (CDC).

Guido Torzilli, Natale Olivari, Eliana Moroni, Daniele Del Fabbro, Andrea Gambetti, Piera Leoni, Marco Montorsi, Masatoshi Makuuchi – 30 January 2004 – Intraoperative ultrasonography (IOUS) is the most accurate diagnostic technique for staging hepatocellular carcinoma (HCC), but has low accuracy in differentiating the new nodules detected in the cirrhotic liver. The aim of this preliminary report is to evaluate whether contrast‐enhanced intraoperative ultrasonography (CE‐IOUS) could provide additional information to IOUS in patients with HCC.

Lorenzo Capussotti, Andrea Muratore, Paolo Massucco, Alessandro Ferrero, Roberto Polastri, Hedayat Bouzari – 30 January 2004 – Since the lack of donors, liver resections continue to be the treatment of choice for cirrhotic patients with good liver function and resectable hepatocellular carcinoma (HCC). Moreover, over the past 2 decades, an increasing number of major hepatic resections have been performed.

Byung Ihn Choi – 30 January 2004 – Early detection of hepatocellular carcinoma (HCC) is important, since the most effective treatment for HCC is surgical resection or local ablation therapy when the tumor is small. Fortunately, recent advances in liver imaging techniques have facilitated the detection of small HCCs.

Jean M. Regimbeau, Magali Colombat, Philippe Mognol, François Durand, Eddie Abdalla, Claude Degott, Françoise Degos, Olivier Farges, Jacques Belghiti – 30 January 2004 – Ten percent of patients who undergo resection for hepatocellular carcinoma (HCC) associated with chronic liver disease have no detectable cause for this underlying liver disease. Recent studies have shown that patients with cryptogenic chronic liver disease frequently have risk factors for nonalcoholic fatty liver disease (NAFLD).

Maria H Sjogren – 30 January 2004

Arndt Vogel, Inge E.T. van den Berg, Muhsen Al‐Dhalimy, John Groopman, Ching‐Nan Ou, Olga Ryabinina, Mihail S. Iordanov, Milton Finegold, Markus Grompe – 30 January 2004 – The murine model of hereditary tyrosinemia type 1 (HT1) was used to analyze the relationship between chronic liver disease and programmed cell death in vivo. In healthy fumarylacetoacetate hydrolase deficient mice (Fah‐/‐), protected from liver injury by the drug 2‐(2‐ nitro‐4‐trifluoromethylbenzoyl)‐1,3‐cyclohexanedione (NTBC), the tyrosine metabolite homogentisic acid (HGA) caused rapid hepatocyte death.