Hepatocyte growth factor induces Mcl‐1 in primary human hepatocytes and inhibits CD95‐mediated apoptosis via Akt

Henning Schulze‐Bergkamen, Dirk Brenner, Andreas Krueger, Dorothee Suess, Stefanie C. Fas, Christian R. Frey, Andreas Dax, Dorothea Zink, Peter Büchler, Martina Müller, Peter H. Krammer – 27 February 2004 – CD95 (APO‐1/Fas)‐mediated apoptosis of hepatocytes plays a central role in the pathophysiology of various human liver diseases. Hepatocyte growth factor (HGF) was shown to exert antiapoptotic functions in rodent hepatocytes. We previously showed that primary human hepatocytes (PHH) are a valuable tool for the investigation of apoptotic processes in liver cells.

Risks of a range of alcohol intake on hepatitis C‐related fibrosis

Alexander Monto, Keyur Patel, Alan Bostrom, Stephen Pianko, Paul Pockros, John G. McHutchison, Teresa L. Wright – 27 February 2004 – Heavy alcohol use contributes to liver disease in the setting of chronic hepatitis C virus (HCV) infection. Whether this is true for light or moderate alcohol use has not been demonstrated. Light alcohol use has survival benefits at a population level and is practiced by most patients with chronic HCV infection.

Liver regeneration after adult living donor and deceased donor split‐liver transplants

Abhinav Humar, Kambiz Kosari, Timothy D. Sielaff, Brooke Glessing, Maria Gomes, Charles Dietz, Galia Rosen, John Lake, William D. Payne – 26 February 2004 – As the number of living donor (LD) and deceased donor (DD) split‐liver transplants (SLTs) have increased over the last 5 years, so too has the interest in liver regeneration after such partial‐liver transplants. We looked at liver regeneration, as measured by computed tomography (CT) volumetrics, to see if there were significant differences among LDs, right‐lobe LD recipients, and SLT recipients.

CC chemokine receptor 5Δ32 polymorphism—a risk factor for ischemic‐type biliary lesions following orthotopic liver transplantation

Christian Moench, Anja Uhrig, Ansgar W. Lohse, Gerd Otto – 26 February 2004 – Ischemic‐type biliary lesions are a major complication following orthotopic liver transplantation. They occur in up to 26% of liver transplant recipients. Among other factors, unknown immunologic factors have always been assumed to be partly responsible for these lesions. CC‐chemokines and their receptors play a key role in postoperative immunomodulation after liver transplantation.

Differences in lymphocyte gene expression between tolerant and syngeneic liver grafted rats

Masayuki Fujino, Yusuke Kitazawa, Mikiko Kawasaki, Naoko Funeshima, Hiromitsu Kimura, Toshiharu Nakajima, Hirohisa Saito, Xiao‐Kang Li – 26 February 2004 – Induction of tolerance to allogeneic donor grafts is a clinically desirable goal in bone marrow and solid organ transplantation. We have taken the advantage of DNA microarray technology to investigate gene expression mechanism in regulatory cells.

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