BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis

Christiane Pauli‐Magnus, Reinhold Kerb, Karin Fattinger, Thomas Lang, Birgit Anwald, Gerd A. Kullak‐Ublick, Ulrich Beuers, Peter J. Meier – 27 February 2004 – Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are characterized by a cholestatic pattern of liver damage, also observed in hereditary or acquired dysfunction of the canalicular membrane transporters bile salt export pump (BSEP, ABCB11) and multidrug resistance protein type 3 (MDR3, ABCB4).

Changing epidemiology of hepatitis B in a U.S. community

W. Ray Kim, Joanne T. Benson, Terry M. Therneau, Heidi A. Torgerson, Barbara P. Yawn, L. Joseph Melton – 27 February 2004 – Despite a reduction in newly acquired hepatitis B virus (HBV) infections since the mid‐1980s, HBV remains an important cause of liver disease in the U.S. We report the prevalence of chronic HBV infection in a U.S. community and describe demographic and clinical characteristics. The Rochester Epidemiology Project records healthcare encounters of residents of Olmsted County, Minnesota.

Body fat distribution, relative weight, and liver enzyme levels: A population‐based study

Saverio Stranges, Joan M. Dorn, Paola Muti, Jo L. Freudenheim, Eduardo Farinaro, Marcia Russell, Thomas H. Nochajski, Maurizio Trevisan – 27 February 2004 – Regional body fat distribution may represent an independent risk factor for several conditions, especially metabolic and cardiovascular diseases; recent findings have shown that abdominal fat accumulation can be an independent predictor of hepatic steatosis.

Flow cytometric isolation of endodermal progenitors from mouse salivary gland differentiate into hepatic and pancreatic lineages

Yuichiro Hisatomi, Kenji Okumura, Kimitoshi Nakamura, Shirou Matsumoto, Ayumi Satoh, Koji Nagano, Tetsuro Yamamoto, Fumio Endo – 27 February 2004 – Experimental injury is useful to induce tissue stem cells, which may exist in small numbers under normal conditions. The salivary glands originate from the endoderm and consist of acinar and ductal epithelial cells, which have exocrine function. After salivary gland duct ligation, acinar cells disappear as a result of apoptosis, and duct epithelium subsequently proliferates.

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