Brendan M. McGuire, Herbert L. Bonkovsky, Robert L. Carithers, Raymond T. Chung, Leonard I. Goldstein, John R. Lake, Anna S. Lok, Carol J. Potter, Elizabeth Rand, Michael D. Voigt, Pamela R. Davis, Joseph R. Bloomer – 28 November 2005 – In erythropoietic protoporphyria (EPP), there is excessive production of protoporphyrin, primarily in the bone marrow, resulting in increased biliary excretion of this heme precursor. Some patients will develop progressive liver disease that may ultimately require liver transplantation.

28 November 2005

Francis Y. Yao, Ryutaro Hirose, Jeanne M. LaBerge, Timothy J. Davern, Nathan M. Bass, Robert K. Kerlan, Raphael Merriman, Sandy Feng, Chris E. Freise, Nancy L. Ascher, John P. Roberts – 28 November 2005 – In patients with hepatocellular carcinoma (HCC) exceeding conventional (T2) criteria for orthotopic liver transplantation (OLT), the feasibility and outcome following loco‐regional therapy intended for tumor downstaging to meet T2 criteria for OLT are unknown.

Ian Gooding, Vicky Dondos, Khin Ma Gyi, Margaret Hodson, David Westaby – 28 October 2005 – Autopsy and imaging studies show that liver involvement is common in cystic fibrosis. However, complications of chronic liver disease including portal hypertension and variceal bleeding are infrequently encountered, and the degree to which variceal hemorrhage affects prognosis in cystic fibrosis is unclear. This uncertainty has lead to debate as to whether liver transplantation is indicated in these patients.

Stefano Ginanni Corradini, Fausta Micheletta, Silvia Natoli, Massimo Iappelli, Emanuele Di Angelantonio, Rosanna De Marco, Walter Elisei, Maria Siciliano, Massimo Rossi, Pasquale Berloco, Adolfo Francesco Attili, Ulf Diczfalusy, Luigi Iuliano – 28 October 2005 – Oxidative stress is implicated in the pathogenesis of hepatic ischemia‐reperfusion injury, a major determinant of initial poor graft function (IPGF) after orthotopic liver transplantation (OLT).

Domenico Sansonno, Felicia Anna Tucci, Valli De Re, Gianfranco Lauletta, Michele Montrone, Massimo Libra, Franco Dammacco – 25 October 2005 – Infection with HCV can be associated with B‐cell non‐Hodgkin lymphoma. Polymerase chain reaction (PCR) amplification assays for Bcl‐2/IgH rearrangement were performed on nucleic acids extracted from portal tract inflammatory infiltrates, isolated with laser capture microdissection (LCM), from liver biopsy sections of 16 hepatitis C virus (HCV)‐infected patients with and without extrahepatic B cell–related disorders.

Robert H. Costa, Vladimir V. Kalinchenko, Yongjun Tan, I‐Ching Wang – 25 October 2005

Sumita Verma, Allan Redeker – 25 October 2005

José E. Manautou, Dirk R. de Waart, Cindy Kunne, Noam Zelcer, Michael Goedken, Piet Borst, Ronald Oude Elferink – 25 October 2005 – MRP3 is an ABC transporter localized in the basolateral membrane of epithelial cells such as hepatocytes and enterocytes. In this study, the role of Mrp3 in drug disposition was investigated. Because Mrp3 preferentially transports glucuronide conjugates, we investigated the in vivo disposition of acetaminophen (APAP) and its metabolites. Mrp3+/+ and Mrp3−/− knockout mice received APAP (150 mg/kg), and bile was collected.

David A. Rudnick – 25 October 2005