Severe hyperthyroidism induces mitochondria‐mediated apoptosis in rat liver

Geeta Upadhyay, Rajesh Singh, Ashok Kumar, Sanjeev Kumar, Amit Kapoor, Madan M. Godbole – 25 March 2004 – Thyrotoxicosis may be associated with a variety of abnormalities of liver function. The pathogenesis of hepatic dysfunction in thyrotoxicosis is unknown, but has been attributed to mitochondrial dysfunction. We studied the effect of altered thyroid function on the apoptotic index in rat liver.

Host factors and failure of interferon‐α treatment in hepatitis C virus

Bin Gao, Feng Hong, Svetlana Radaeva – 25 March 2004 – Failure of interferon‐α (IFN‐α) treatment in patients with chronic hepatitis C virus (HCV) infection is a challenging obstacle for clinical and experimental hepatology. Both viral and host factors have been implicated in reducing responsiveness to IFN‐α therapy. The role of viral factors has been studied extensively and has been summarized in several review articles; however, much less attention has been paid to host factors. In this paper, we review evidence of host factor involvement in IFN‐α treatment failure.

5′‐methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes

Henar Hevia, Marta Varela‐Rey, Fernando J. Corrales, Carmen Berasain, María L. Martínez‐Chantar, M. Ujue Latasa, Shelly C. Lu, José M. Mato, Elena R. García‐Trevijano, Matías A. Avila – 25 March 2004 – 5′‐methylthioadenosine (MTA) is a nucleoside generated from S‐adenosylmethionine (AdoMet) during polyamine synthesis. Recent evidence indicates that AdoMet modulates in vivo the production of inflammatory mediators.

Expression of Notch‐1 and its ligand Jagged‐1 in rat liver during liver regeneration

Christoph Köhler, Aaron W. Bell, William C. Bowen, Satdarshan P. Monga, Wolfgang Fleig, George K. Michalopoulos – 25 March 2004 – The Notch/Jagged signaling pathway is important for cellular differentiation and proliferation. Its dysfunction is associated with human pathologies in several tissues including liver. Point mutations in Jagged‐1 gene are the cause for Alagille syndrome, associated with paucity of intrahepatic bile ducts.

Identification of discriminators of hepatoma by gene expression profiling using a minimal dataset approach

Soek Ying Neo, Chon Kar Leow, Vinsensius B. Vega, Philip M. Long, Amirul F.M. Islam, Paul B.S. Lai, Edison T. Liu, Ee Chee Ren – 25 March 2004 – The severity of hepatocellular carcinoma (HCC) and the lack of good diagnostic markers and treatment strategies have rendered the disease a major challenge. Previous microarray analyses of HCC were restricted to the selected tissue sample sets without validation on an independent series of tissue samples. We describe an approach to the identification of a composite discriminator cassette by intersecting different microarray datasets.

Immunohistochemical analysis of Mallory bodies in Wilsonian and non‐Wilsonian hepatic copper toxicosis

Thomas Müller, Cord Langner, Andrea Fuchsbichler, Peter Heinz‐Erian, Helmut Ellemunter, Barbara Schlenck, Ashish R. Bavdekar, Avinash M. Pradhan, Anand Pandit, Josef Müller‐Höcker, Michael Melter, Kunihiko Kobayashi, Hironori Nagasaka, Hideaki Kikuta, Wilfried Müller, M.

Hepatitis C virus‐infected patients report communication problems with physicians

Susan Zickmund, Stephen L. Hillis, Mitchell J. Barnett, Laura Ippolito, Douglas R. LaBrecque – 25 March 2004 – We examined the prevalence and nature of perceived problems in the interaction between physicians and patients diagnosed with hepatitis C virus (HCV) infection. This cross‐sectional study included 322 outpatients diagnosed with chronic HCV infection and treated at a tertiary referral hospital's hepatology clinic.

Kupffer cells required for high affinity peptide‐induced deletion, not retention, of activated CD8+ T cells by mouse liver

Yuhshi Kuniyasu, Suhail Mohammed Marfani, Irteza Bin Inayat, Shehzad Zafar Sheikh, Wajahat Zafar Mehal – 25 March 2004 – The immune response to foreign antigens in the liver is often suboptimal and this is clinically relevant in chronic persistence of hepatotropic viruses. In chronic infection with the hepatitis C virus, activated CD8+ T cells specific for viral epitopes are present in the peripheral blood and the liver, yet viral clearance is unusual.

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