Stephen H. Caldwell, Charissa Chang, B. Gail Macik – 27 February 2004 – The management of coagulopathy in patients with acute and chronic liver disease has undergone little change in many years despite advances in our understanding of the pathogenesis of this problem. In general, deficiency of clotting factors as a result of poor hepatic synthetic function accounts for most of the coagulopathy.

Anna S.F. Lok, Brian J. McMahon – 27 February 2004

Nicolas André, Bertrand Roquelaure, Isabelle Thuret, Marianne Ziol, Frédéric Rieux‐Laucat, Françoise Le Deist – 27 February 2004

Juan Rodés – 27 February 2004

Sophie Le Calvez, Dominique Thabut, Djamila Messous, Mona Munteanu, Vlad Ratziu, Francoise Imbert‐Bismut, Thierry Poynard – 27 February 2004

Marina Tinel, Alain Berson, Nathalie Vadrot, Véronique Descatoire, Alain Grodet, Gérard Feldmann, Jean Paul Thénot, Dominique Pessayre – 27 February 2004 – The hepatotoxicity of several drugs is increased by mild viral infections. During such infections, death receptor ligands are expressed at low levels, and most parenchymal cells survive. We tested the hypothesis that subliminal death receptor stimulation may aggravate the hepatotoxicity of drugs, which are transformed by cytochrome P‐450 cytochrome P‐450 into glutathione‐depleting reactive metabolites.

27 February 2004

Fuyumi Isayama, Matthias Froh, Ming Yin, Lars O. Conzelmann, Richard J. Milton, Stephen E. McKim, Michael D. Wheeler – 27 February 2004 – Tumor necrosis factor α (TNFα) has been shown to be both proapoptotic and mitogenic for hepatocytes and necessary for alcohol‐induced liver injury. Ras, a known proto‐oncogene, is very important in the regulation of cellular responses to TNFα. Therefore, the purpose of this study was to investigate the role of Ras in alcohol‐induced pathogenesis. Male C57Bl/6 mice were fed ethanol or high‐fat control diet via intragastric cannulation for 4 weeks.

Jeanne M. Clark, Frederick L. Brancati – 27 February 2004

Dan Takeuchi, Hiroyuki Yoshidome, Atsushi Kato, Hiroshi Ito, Fumio Kimura, Hiroaki Shimizu, Masayuki Ohtsuka, Yasuhiro Morita, Masaru Miyazaki – 27 February 2004 – Hepatic ischemia/reperfusion injury is a clinically important problem. While the mechanisms of the initial event and subsequent neutrophil‐dependent injury are somewhat understood, little is known about the regulation of endogenous hepatoprotective effects on this injury. Interleukin 12 (IL‐12) plays a role in the induction of this injury, but involvement of interleukin 18 (IL‐18) has not been clarified.