BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis

Christiane Pauli‐Magnus, Reinhold Kerb, Karin Fattinger, Thomas Lang, Birgit Anwald, Gerd A. Kullak‐Ublick, Ulrich Beuers, Peter J. Meier – 27 February 2004 – Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are characterized by a cholestatic pattern of liver damage, also observed in hereditary or acquired dysfunction of the canalicular membrane transporters bile salt export pump (BSEP, ABCB11) and multidrug resistance protein type 3 (MDR3, ABCB4).

Gene expression pattern in hepatic stem/progenitor cells during rat fetal development using complementary DNA microarrays

Petko M. Petkov, Jiri Zavadil, David Goetz, Tearina Chu, Robert Carver, Charles E. Rogler, Erwin P. Bottinger, David A. Shafritz, Mariana D. Dabeva – 27 February 2004 – To identify new and differentially expressed genes in rat fetal liver epithelial stem/progenitor cells during their proliferation, lineage commitment, and differentiation, we used a high throughput method—mouse complementary DNA (cDNA) microarrays—for analysis of gene expression. The gene expression pattern of rat hepatic cells was studied during their differentiation in vivo: from embryonic day (ED) 13 until adulthood.

Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress

Gaetano Serviddio, Javier Pereda, Federico V. Pallardó, Julian Carretero, Consuelo Borras, Juan Cutrin, Gianluigi Vendemiale, Giuseppe Poli, José Viña, Juan Sastre – 27 February 2004 – Ursodeoxycholic acid (UDCA) improves clinical and biochemical indices in primary biliary cirrhosis and prolongs survival free of liver transplantation. Recently, it was suggested that the cytoprotective mechanisms of UDCA may be mediated by protection against oxidative stress, which is involved in the development of cirrhosis induced by chronic cholestasis.

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