Fuyumi Isayama, Matthias Froh, Ming Yin, Lars O. Conzelmann, Richard J. Milton, Stephen E. McKim, Michael D. Wheeler – 27 February 2004 – Tumor necrosis factor α (TNFα) has been shown to be both proapoptotic and mitogenic for hepatocytes and necessary for alcohol‐induced liver injury. Ras, a known proto‐oncogene, is very important in the regulation of cellular responses to TNFα. Therefore, the purpose of this study was to investigate the role of Ras in alcohol‐induced pathogenesis. Male C57Bl/6 mice were fed ethanol or high‐fat control diet via intragastric cannulation for 4 weeks.

27 February 2004

Marina Tinel, Alain Berson, Nathalie Vadrot, Véronique Descatoire, Alain Grodet, Gérard Feldmann, Jean Paul Thénot, Dominique Pessayre – 27 February 2004 – The hepatotoxicity of several drugs is increased by mild viral infections. During such infections, death receptor ligands are expressed at low levels, and most parenchymal cells survive. We tested the hypothesis that subliminal death receptor stimulation may aggravate the hepatotoxicity of drugs, which are transformed by cytochrome P‐450 cytochrome P‐450 into glutathione‐depleting reactive metabolites.

Sophie Le Calvez, Dominique Thabut, Djamila Messous, Mona Munteanu, Vlad Ratziu, Francoise Imbert‐Bismut, Thierry Poynard – 27 February 2004

Juan Rodés – 27 February 2004

Nicolas André, Bertrand Roquelaure, Isabelle Thuret, Marianne Ziol, Frédéric Rieux‐Laucat, Françoise Le Deist – 27 February 2004

Anna S.F. Lok, Brian J. McMahon – 27 February 2004

Stephen H. Caldwell, Charissa Chang, B. Gail Macik – 27 February 2004 – The management of coagulopathy in patients with acute and chronic liver disease has undergone little change in many years despite advances in our understanding of the pathogenesis of this problem. In general, deficiency of clotting factors as a result of poor hepatic synthetic function accounts for most of the coagulopathy.

Anna Serafín, Joan Roselló‐Catafau, Neus Prats, Emilio Gelpí, Joan Rodés, Carmen Peralta – 27 February 2004 – The present study evaluates the effect of ischemic preconditioning on interleukin‐1 (IL‐1) and interleukin‐10 (IL‐10) generation following hepatic ischemia/reperfusion (I/R) in normal and steatotic livers as well as the role of nitric oxide (NO) in this process. Increased IL‐1β and IL‐10 levels were observed in normal livers after I/R. Steatotic livers showed higher IL‐1β levels than normal livers, and IL‐10 at control levels.

Edmond Schmied, Jean‐François Dufour, Sylvie Euvrard – 26 February 2004 – The skin, easily accessible for medical examination, is affected in many ways by liver transplantation. Mucocutaneous manifestations of advanced liver disease and dermatologic conditions associated with specific hepatic diagnoses generally improve after liver transplantation. Vasculitic lesions due to cryoglobulinemia associated with hepatitis C, and photosensitivity due to porphyria are occasional exceptions. Dermatologic diseases complicating the posttransplantation course can be challenging.