Recurrent herpes simplex virus hepatitis after liver retransplantation despite acyclovir therapy

Thomas Longerich, Christoph Eisenbach, Roland Penzel, Thomas Kremer, Christa Flechtenmacher, Burkhard Helmke, Jens Encke, Thomas Kraus, Peter Schirmacher – 23 September 2005 – Herpes virus hepatitis (HSV) represents a form of acute necrotizing hepatitis, which most frequently develops in immunocompromised patients. Therapeutic options include high‐dose intravenous acyclovir and liver transplantation. We report the first case of recurrent HSV hepatitis after liver retransplantation, which occurred despite continuous administration of high‐dose intravenous antiviral therapy.

Early hepatic stellate cell activation predicts severe hepatitis C recurrence after liver transplantation

Samer Gawrieh, Bettina G. Papouchado, Lawrence J. Burgart, Shogo Kobayashi, Michael R. Charlton, Gregory J. Gores – 23 September 2005 – Only a subset of hepatitis C virus (HCV)‐infected patients develop progressive hepatic fibrosis after liver transplantation (LT). Hepatic stellate cell (HSC) activation is a pivotal step in hepatic fibrosis and precedes clinically apparent fibrosis. We determined whether early HSC activation, measured in 4‐month protocol post‐LT biopsies, is predictive of subsequent development of more histologically severe recurrence of HCV.

Resection for hepatocellular carcinoma is a good option in Child‐Turcotte‐Pugh class A patients with cirrhosis who are eligible for liver transplantation

Carlos Margarit, Alfredo Escartín, Lluis Castells, Víctor Vargas, Elena Allende, Itxarone Bilbao – 23 September 2005 – The best treatment option for patients with single, early hepatocellular carcinoma (HCC) and cirrhosis, good liver function, and absence of portal hypertension remains to be established. The aim of this work was to compare the outcome of liver resection (LR) with that of liver transplantation (LT) for single, early HCC in Child‐Turcotte‐Pugh class A patients with cirrhosis younger than 70 years of age.

Living domino liver transplantation in an adult with congenital absence of portal vein

Takayuki Takeichi, Hideaki Okajima, Hiroko Suda, Shintarou Hayashida, Hironori Iwasaki, Manuel Zeledon Ramirez, Mikako Ueno, Katsuhiro Asonuma, Yukihiro Inomata – 23 September 2005 – Congenital absence of the portal vein (CAPV) is a rare malformation of the splanchnic venous system. Although CAPV is usually detected in the pediatric age group, our patient was a 35‐year‐old woman. She had been diagnosed with CAPV in 1996 when she was 27 years old. In 1998, she was placed on hemodialysis due to chronic renal failure.

Evaluation for liver transplantation: Adherence to AASLD referral guidelines in a large veterans affairs center

Venodhar R. Julapalli, Jennifer R. Kramer, Hashem B. El‐Serag – 23 September 2005 – Access of patients to liver transplantation involves three levels: referral for evaluation for transplantation, placement on a waiting list for transplantation, and receipt of a liver transplant. No study has formally evaluated access to liver transplantation at the referral level. Therefore, we sought to estimate the magnitude and determinants of consideration of liver transplantation in patients at a single, large Veterans Affairs medical center.

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