Neil Kaplowitz – 15 July 2005

Gregory T. Everson, James Trotter, Lisa Forman, Marcelo Kugelmas, Arthur Halprin, Barbara Fey, Catherine Ray – 15 July 2005 – Patients with advanced hepatitis C virus (HCV) are at risk of death and are candidates for liver transplantation. After transplantation, HCV recurs and may rapidly progress to cirrhosis and graft loss. Treatment is needed to prevent progression of disease and minimize recurrence after liver transplantation.

Gianluca Svegliati‐Baroni, Yutaka Inagaki, Ana‐Rosa Rincon‐Sanchez, Cindy Else, Stefania Saccomanno, Antonio Benedetti, Francesco Ramirez, Marcos Rojkind – 15 July 2005 – Acetaldehyde is fibrogenic and induces the expression of type I collagen genes in hepatic stellate cells. Some of these acetaldehyde‐dependent events are mediated by H2O2 and thus establish a direct connection between oxidative stress and collagen upregulation.

Adrian Reuben – 15 July 2005

Avidan U. Neumann – 15 July 2005

Kurt Lenz – 15 July 2005

Xing Xian Yu, Susan F. Murray, Sanjay K. Pandey, Sheri L. Booten, Dingjiu Bao, Xiu‐Zhen Song, Susan Kelly, Songyuan Chen, Robert McKay, Brett P. Monia, Sanjay Bhanot – 6 July 2005 – In this study, we investigated the role of acyl‐coenzyme A:diacylglycerol acyltransferase 2 (DGAT2) in glucose and lipid metabolism in obese mice by reducing its expression in liver and fat with an optimized antisense oligonucleotide (ASO). High‐fat diet‐induced obese (DIO) C57BL/6J mice and ob/ob mice were treated with DGAT2 ASO, control ASO, or saline.

Daryl T.‐Y. Lau, Bruce A. Luxon, Shu‐Yuan Xiao, Michael R. Beard, Stanley M. Lemon – 28 June 2005 – To gain insight into pathogenic mechanisms underlying fibrosis in hepatitis C virus (HCV)‐mediated liver injury, we compared intrahepatic gene expression profiles in HCV‐infected patients at different stages of fibrosis and α‐smooth muscle actin (α‐SMA) staining patterns. We studied 21 liver biopsy specimens: 5 had no fibrosis (Ludwig‐Batts stage 0); 10 had early portal or periportal fibrosis (stages 1 and 2); and 6, advanced fibrosis (stages 3 and 4).

Martin Wagner, Emina Halilbasic, Hanns‐Ulrich Marschall, Gernot Zollner, Peter Fickert, Cord Langner, Kurt Zatloukal, Helmut Denk, Michael Trauner – 28 June 2005 – Induction of hepatic phase I/II detoxification enzymes and alternative excretory pumps may limit hepatocellular accumulation of toxic biliary compounds in cholestasis. Because the nuclear xenobiotic receptors constitutive androstane receptor (CAR) and pregnane X receptor (PXR) regulate involved enzymes and transporters, we aimed to induce adaptive alternative pathways with different CAR and PXR agonists in vivo.

Heinz Zoller, Ian McFarlane, Igor Theurl, Sylvia Stadlmann, Elizabeta Nemeth, David Oxley, Tomas Ganz, David J. Halsall, Timothy M. Cox, Wolfgang Vogel – 28 June 2005 – Ferroportin disease (hemochromatosis type 4) is a recently recognized disorder of human iron metabolism, characterized by iron deposition in macrophages, including Kupffer cells. Mutations in the gene encoding ferroportin 1, a cellular iron exporter, are responsible for this iron storage disease, inherited as an autosomal dominant trait.