Patrick L. Splinter, Anatoliy I. Masyuk, Raul A. Marinelli, Nicholas F. LaRusso – 5 January 2004 – Rodent cholangiocytes express 6 of the 11 known channel proteins called aquaporins (AQPs) that are involved in transcellular water transport in mammals. However, clarifying the role of AQPs in mediating water transport in biliary epithelia has been limited in part because of the absence of physiologically relevant experimental models.

Hiroaki Shibahara, Shugo Tamada, Michiyo Higashi, Masamichi Goto, Surinder K. Batra, Michael A. Hollingsworth, Kohzoh Imai, Suguru Yonezawa – 5 January 2004 – Complete surgical resection of the tumor is the sole approach to improve the cure rate of patients with intrahepatic cholangiocarcinoma‐mass forming type (ICC‐MF). Although patients are treated by curative resection, many of them show poor outcome.

Jinah Choi, Ki Jeong Lee, Yanyan Zheng, Ardath K. Yamaga, Michael M.C. Lai, Jing‐hsiung Ou – 5 January 2004 – Hepatitis C virus (HCV) is a positive‐stranded RNA virus that causes severe liver diseases, such as cirrhosis and hepatocellular carcinoma. HCV uses an RNA‐dependent RNA polymerase to replicate its genome and an internal ribosomal entry site to translate its proteins. HCV infection is characterized by an increase in the concentrations of reactive oxygen species (ROS), the effect of which on HCV replication has yet to be determined.

Jenny Heathcote – 5 January 2004

Stephen F. Stewart, Matteo Vidali, Christopher P. Day, Emanuele Albano, David E.J. Jones – 5 January 2004 – Serum antibodies reactive with neo‐antigens generated during ethanol metabolism have been identified in patients with alcoholic liver disease (ALD), although their role in the pathogenesis of disease remains unclear.

Claudia O. Zein, Keith D. Lindor, Paul Angulo – 5 January 2004 – Patients with primary sclerosing cholangitis (PSC) may develop and bleed from esophageal varices. However, the exact prevalence of esophageal varices in patients with PSC remains unknown and potential predictors of esophageal varices in this population have not been identified. Our aim was to determine the prevalence of esophageal varices in patients with PSC and the variables that predict their presence.

Don C. Rockey, Vijay Shah – 5 January 2004

5 January 2004

5 January 2004

Markus Grompe – 5 January 2004