Changes in oxyhemoglobin dissociation curve in intrabdominal organs during pig experimental orthotopic liver transplantation

Georgia Kostopanagiotou, Kassiani Theodoraki, Ageliki Pandazi, Nikolaos Arkadopoulos, Konstantinos Kostopanagiotou, Vassilios Smyrniotis – 22 June 2005 – Liver transplantation has become a gold standard treatment for irreversible liver disease. Conventional measures of oxygenation are inadequate to understand the dynamics of regional oxygen metabolism during liver transplantation because they represent global markers of tissue dysoxia.

Right hepatic lobe donation adversely affects donor life insurability up to one year after donation

Matthew H. Nissing, Paul H. Hayashi – 22 June 2005 – There are no data regarding hepatic lobe donation effects on donor life insurability. Two investigators called 10 agents of 10 different large life insurance companies. One investigator gave a fictitious profile: Caucasian man, 33 years old, nonsmoker, without medical problems (control profile [CP]). The other investigator used the same profile with a history of uncomplicated right lobe donation 12 months earlier (donor profile [DP]). Investigators asked for premium quotes on a $100,000 term life policy.

Hepatic B‐cell non‐Hodgkin's lymphoma of MALT type in the liver explant of a patient with chronic hepatitis C infection

Mauricio Orrego, Linsheng Guo, Craig Reeder, Giovanni De Petris, Vijayan Balan, David D. Douglas, Thomas Byrne, Edwyn Harrison, David Mulligan, Hector Rodriguez‐Luna, Adyr Moss, Kunam Reddy, Jorge Rakela, Hugo E. Vargas – 22 June 2005 – B‐cell non‐Hodgkin's lymphoma (B‐NHL) is a well‐documented complication of hepatitis C virus (HCV) infection. Marginal zone (mucosa‐associated lymphoid tissue; MALT) lymphomas constitute a less common type of B‐NHL. In this article, we report a case of liver MALT in a cirrhotic patient, incidentally discovered after liver transplantation (LT).

Liver transplantation for HCV‐related cirrhosis in a patient with gastric mucosa‐associated lymphoma (MALToma) pretreated with rituximab

Matthew R. Foxton, Lisa Knight, Alex S. Knisely, Ghulam J. Mufti, John O'Grady, Paolo Muiesan, Suzanne Norris – 22 June 2005 – End‐stage liver disease due to chronic hepatitis C virus (HCV) infection is now the most frequent indication for liver transplantation. HCV infection is associated with extrahepatic disease including cryoglobulinemia and lymphoma.

Hepatitis C virus–specific CD8+ T cells restricted by donor HLA alleles following liver transplantation

George M. Lauer – 22 June 2005 – By necessity, human liver transplantation is performed across HLA barriers. As a result, intracellular infection of the allograft presents a unique immunologic challenge for the recipient's immune system. In this study, we describe the presence of HLA‐A2‐restricted, hepatitis C virus (HCV)‐specific CD8+ T cells in liver transplant recipients in whom the allograft is HLA‐A2 positive and the recipient is HLA‐A2 negative. These memory‐effector T cells are recipient derived and recognize HCV peptide uniquely in the context of HLA‐A2.

Genotype–phenotype relationships in hepatocellular tumors from mice and man

Sabine Stahl, Carina Ittrich, Philip Marx‐Stoelting, Christoph Köhle, Özge Altug‐Teber, Olaf Riess, Michael Bonin, Jürgen Jobst, Stephan Kaiser, Albrecht Buchmann, Michael Schwarz – 17 June 2005 – Experimentally induced liver tumors in mice harbor activating mutations in either Catnb (β‐catenin) or Ha‐ras, according to the carcinogenic treatment. We have now investigated by microarray analysis the gene expression profiles in tumors of the two genotypes.

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