Alex B. Lentsch – 16 June 2005 – The inhibitor of NF‐κB (I‐κB) kinase (IKK) complex consists of 3 subunits, IKK1, IKK2, and NF‐κB essential modulator (NEMO), and is involved in the activation of NF‐κB by various stimuli. IKK2 or NEMO constitutive knockout mice die during embryogenesis as a result of massive hepatic apoptosis. Therefore, we examined the role of IKK2 in TNF‐induced apoptosis and ischemia/reperfusion (I/R) injury in the liver by using conditional knockout mice.

Michael A. Heneghan, Ian G. McFarlane – 16 June 2005

Jarmila D. W. van der Bilt, Onno Kranenburg, Maarten W. Nijkamp, Niels Smakman, Liesbeth M. Veenendaal, Elisabeth A. te Velde, Emile E. Voest, Paul J. van Diest, Inne H. M. Borel Rinkes – 16 June 2005 – Mortality in colorectal cancer is associated with the development of liver metastases. Surgical removal of these tumors is the only hope for cure, but recurrence is common. During liver surgery, ischemia/reperfusion (I/R) often occurs as a result of hemorrhage or vascular clamping.

Thomas D. Boyer – 16 June 2005

Thomas F. Baumert, Josef Köck, Hubert E. Blum – 16 June 2005

Elizabeth E. Powell, Julie R. Jonsson, Andrew D. Clouston – 16 June 2005 – The prevalence of fatty liver is rising in association with the global increase in obesity and type 2 diabetes. In the past, simple steatosis was regarded as benign, but the presence of another liver disease may provide a synergistic combination of steatosis, cellular adaptation, and oxidative damage that aggravates liver injury.

Yuichi Nagakawa, George Melville Williams, Qizhi Zheng, Akihiko Tsuchida, Tatsuya Aoki, Robert A. Montgomery, Andrew S. Klein, Zhaoli Sun – 16 June 2005 – An orthotopic liver transplant model in the rat was used to evaluate the role of tumor necrosis factor alpha (TNF‐α) in liver transplant rejection. There were significantly increased levels of TNF‐α mRNA and parallel increases in 8‐hydroxy‐2′ deoxyguanosine (8‐OHdG) indicative of oxidative DNA damage present 7 to 12 days after transplantation.

Vassiliki‐Anastasia Sypsa, Konstantinos Mimidis, Nicholas C. Tassopoulos, Dimitrios Chrysagis, Themistoklis Vassiliadis, Antonios Moulakakis, Maria Raptopoulou, Caterina Haida, Angelos Hatzakis – 16 June 2005 – We studied viral dynamic parameters in 44 chronic hepatitis B/hepatitis B e antigen (HBeAg)(−) patients treated with pegylated interferon alfa‐2b (PEG‐IFN) 100 or 200 μg weekly or lamivudine 100 mg daily or the combination of PEG‐IFN 100 or 200 μg with lamivudine.

James W. Mosley, Eva A. Operskalski, Leslie H. Tobler, William W. Andrews, Bruce Phelps, Janel Dockter, Cristina Giachetti, Michael P. Busch – 13 June 2005 – Since 1980, the Transfusion‐transmitted Viruses Study (TTVS) (1974–1980) has continued to maintain its computerized database and stored sera to enable ongoing study of new transfusion events since the 1970s. Most recently, we have used this resource to study parameters of acute hepatitis C virus (HCV) infection among 94 donor–recipient pairs in which there was transmission.

Luigi Bolondi, Stefano Gaiani, Natascia Celli, Rita Golfieri, Walter Francesco Grigioni, Simona Leoni, Anna Maria Venturi, Fabio Piscaglia – 13 June 2005 – In a prospective study, we examined the impact of arterial hypervascularity, as established by the European Association for the Study of the Liver (EASL) recommendations, as a criterion for characterizing small (1‐3 cm) nodules in cirrhosis. A total of 72 nodules (1‐2 cm, n = 41; 2.1‐3 cm, n = 31) detected by ultrasonography in 59 patients with cirrhosis were included in the study.