Aránzazu Sánchez, Valentina M. Factor, Luis A. Espinoza, Insa S. Schroeder, Snorri S. Thorgeirsson – 30 August 2004 – Hepatic stem cells are activated after liver damage and have a critical role in tissue homeostasis and repair. Characterization of molecular and cellular events accompanying the expansion and differentiation of liver stem cells is essential for understanding the basic biology of stem cells and for facilitating clinical application of the stem cells.

Renate G. van der Molen, Dave Sprengers, Rekha S. Binda, Esther C. de Jong, Hubert G. M. Niesters, Johannes G. Kusters, Jaap Kwekkeboom, Harry L. A. Janssen – 30 August 2004 – Dendritic cells (DC) play an important role in the induction of T‐cell responses. We hypothesize that the hampered antiviral T‐cell response in chronic hepatitis B patients is a result of impaired dendritic cell function.

30 August 2004

Anna Feliu, Eugeni Gay, Montserrat García‐Retortillo, Juan Carlos Saiz, Xavier Forns – 30 August 2004 – Liver cirrhosis caused by chronic hepatitis C virus (HCV) infection is the main indication for liver transplantation (LT). There is little information on HCV genetic evolution following transplantation. The aim of this study was to carefully assess early evolution of HCV quasispecies in a cohort of 18 liver transplant recipients followed prospectively.

Kwang‐Woong Lee, Jae Won Joh, Sung Joo Kim, Seong Ho Choi, Jin Seok Heo, Hwan Hyo Lee, Jean Wan Park, Suk‐Koo Lee – 30 August 2004 – Biliary complications after living donor liver transplantation (LDLT) continue to be problematic. For reducing the biliary complications, the authors applied an intrahepatic Glissonian approach to the recipient hepatectomy. We called this Glissonian dissection technique at the high hilar level high hilar dissection (HHD). In this study, we introduced this HHD technique and evaluated its outcome in 31 recipients of a living donor liver transplant (LDLT).

He‐Xin Yan, Hong‐Yang Wang, Rui Zhang, Lei Chen, Bao‐An Li, Shu‐Qin Liu, Hui‐Fang Cao, Xiu‐Hua Qiu, Yun‐Feng Shan, Zhong‐Hua Yan, Hong‐Ping Wu, Ye‐Xiong Tan, Meng‐Chao Wu – 30 August 2004 – Signal regulatory protein (SIRP) α1 is a member of the SIRP family that undergoes tyrosine phosphorylation and binds SHP‐2 tyrosine phosphatase in response to various mitogens. The expression levels of SIRPα1 were decreased in HCC tissues, compared with the matched normal tissues.

Sophie Girard, Erik Vossman, David E. Misek, Philippe Podevin, Samir Hanash, Christian Bréchot, Laura Beretta – 30 August 2004 – Most individuals exposed to hepatitis C virus (HCV) become chronically infected and are predisposed to liver disease. The mechanisms underlying viral persistence and disease progression are unknown. A role for the HCV NS5A protein in viral replication and interferon resistance has been demonstrated. To identify mechanisms affected by NS5A, we analyzed the gene expression of Huh7 cells expressing NS5A and control cells using oligonucleotide microarrays.

Ernesto P. Molmenti, Davinder S. Grover, Paul J. Thuluvath, Hyun S. Kim, Duke E. Cameron, Andreas G. Tzakis, Andrew S. Klein – 30 August 2004

Isabel Aguilera, Jose M. Sousa, Francisco Gavilán, Angel Bernardos, Ingeborg Wichmann, Antonio Nuñez‐Roldán – 30 August 2004 – A new form of autoimmune hepatitis referred to as de novo, has been reported after liver transplantation during the past 5 years. The features are identical to those of classical autoimmune hepatitis (AIH), but the facts involved in the onset and outcome of this type of graft dysfunction are still unclear.

Matteo Ravaioli, Giorgio Ercolani, Matteo Cescon, Gaetano Vetrone, Claudio Voci, Walter Franco Grigioni, Antonia D'Errico, Giorgio Ballardini, Antonino Cavallari, Gian Luca Grazi – 30 August 2004 – The selection criteria in liver transplantation for HCC are a matter of debate. We reviewed our series, comparing two periods: before and after 1996, when we started to apply the Milan criteria. The study population was composed of patients with a preoperative diagnosis of HCC, confirmed by the pathological report and with a survival of >1 year.