William D. Payne – 30 December 2003

Amadeo Marcos – 30 December 2003

Julie R. Jonsson, Cui Hong, David M. Purdie, Carmel Hawley, Nicky Isbel, Maree Butler, Glenda A. Balderson, Andrew D. Clouston, Nirmala Pandeya, Katherine Stuart, Catherine Edwards‐Smith, Darrell H. Crawford, Jonathon Fawcett, Elizabeth E. Powell – 30 December 2003 – Although immunosuppressive regimens are effective, rejection occurs in up to 50% of patients after orthotopic liver transplantation (OLT), and there is concern about side effects from long‐term therapy.

Geoffrey Haydon, James Neuberger – 30 December 2003

Viswanath B. Unnithan, Suzanne H.E. Veehof, Philip Rosenthal, Christine Mudge, Teresa H. O'Brien, Patricia Painter – 30 December 2003 – Liver transplantation is accepted as the standard management for end‐stage liver disease in children. Pediatric heart and heart‐lung transplant recipients have shown significantly diminished exercise capacities compared with age‐matched, able‐bodied, control subjects.

Rajiv Jalan, David E. Newby, Steven W.M. Olde Damink, Doris N. Redhead, Peter C. Hayes, Alistair Lee – 30 December 2003 – This report describes the instantaneous changes in cerebral blood flow (CBF), determined by intravascular ultrasound and Doppler, in a patient with cirrhosis undergoing placement of a transjugular intrahepatic stent‐shunt for uncontrolled variceal bleeding. Acute changes in CBF were observed during and after portasystemic shunting, which culminated in cerebral edema and cerebral herniation.

Yukihiro Inomata, Taro Nakamura, Shinji Uemoto, Koichi Tanaka, Go Wakabayashi, Motohide Shimazu – 30 December 2003 – The liver from a patient with familial amyloid polyneuropathy (FAP) scheduled for living donor liver transplantation can be split and transplanted into 2 adult patients with end‐stage liver disease. We have performed this procedure, called domino split transplantation, twice. The native liver was split in situ in 1 patient with FAP and ex situ in the other patient with FAP.

D. Montgomery Bissell, Dominique Roulot, Jacob George – 30 December 2003

Nobuhiro Ikuno, Marita Scealy, Janet M. Davies, Senga F. Whittingham, Katsuhisa Omagari, Ian R. Mackay, Merrill J. Rowley – 30 December 2003 – Primary biliary cirrhosis (PBC) and autoimmune cholangitis (AIC) are serologic expressions of an autoimmune liver disease affecting biliary ductular cells.

Giovanni Rolla, Luisa Brussino, Luca Dutto, Antonio Ottobrelli, Caterina Bucca – 30 December 2003 – Severe hypoxemia may occur in patients with liver disease as a result of abnormal intrapulmonary vasodilatations (hepatopulmonary syndrome, HPS). Liver transplantation (LT) is the only effective treatment of HPS, with a quite variable delay of improvement of oxygenation. Smoking, by decreasing respiratory nitric oxide (NO), apparently contributed to improved oxygenation in a 44‐year‐old man with alcohol‐induced cirrhosis, complicated by HPS, who underwent LT.