Insulin in UW solution exacerbates hepatic ischemia / reperfusion injury by energy depletion through the IRS‐2 / SREBP‐1c pathway
Xian Liang Li, Kwan Man, Kevin T. Ng, Terence K. Lee, Chung Mau Lo, Sheung Tat Fan – 30 August 2004 – Ischemia / reperfusion (I / R) injury is related to tissue graft energy status. Insulin, which is currently used in the University of Wisconsin (UW) preservation solution with insulin (UWI), is an anabolic hormone and was shown to exacerbate the hepatic I / R injury in our previous study. In this study, the energy status and regulation of metabolism genes by insulin were investigated in liver grafts preserved by UW solution.