Magnetic resonance microscopy and histopathology: Comparative approach of bromobenzene‐induced hepatotoxicity in the rat

Marielle Delnomdedieu, Laurence W. Hedlund, Robert R. Maronpot, G. Allan Johnson – 30 December 2003 – The development of magnetic resonance (MR) microscopy has provided new approaches to histology and histopathology. Recent work has shown the promise of increased sensitivity in animal models of chemically induced hepatotoxicity. However, the field is so new that there is little experience to relate changes seen in MR micrographs to the more traditional optical images stained with hematoxylin and eosin.

Cytochrome P4502A6 (CYP2A6) expression in human hepatocellular carcinoma

Hannu Raunio, Risto Juvonen, Markku Pasanen, Olavi Pelkonen, Paavo Pääkkö, Ylermi Soini – 30 December 2003 – The hepatic cytochrome P4502A6 (CYP2A6) enzyme mediates the oxidative metabolism of several procarcinogens that have liver as their primary target. Mouse models indicate that liver tumors invariably overexpress CYP2A forms, and that inflammation and cirrhosis may regulate the CYP2A expression pattern. In this study, the distribution of the CYP2A6 protein was investigated in a series of 24 human hepatocellular carcinoma (HCC) samples by immunohistochemical analysis.

Enhanced Na+‐dependent bile salt uptake by WIF‐B cells, a rat hepatoma hybrid cell line, following growth in the presence of a physiological bile salt

Elisa M. Konieczko, Amy K. Ralston, Aleta R. Crawford, Saul J. Karpen, James M. Crawford – 30 December 2003 – Although bile salts are toxic to the liver at high plasma concentrations, the effects of physiological concentrations of bile salts on normal hepatic function are poorly understood. We examined the effect of taurocholate (TC) on the basolateral uptake of [3H]TC in WIF‐B cells, a hybrid cell line stably exhibiting in vitro the structural and functional polarity of hepatocytes.

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