Anti‐selectin therapy against hepatic ischemia‐reperfusion injury

Hartmut Jaeschke – 30 December 2003 – Evidence shows that leukocyte recruitment into inflamed liver sinusoids does not require selectins, with one notable exception: ischemia‐reperfusion (I/R). We used intravital microscopy to directly visualize the liver microcirculation during I/R and localized endotoxemia (liver superfused with lipopolysaccharide). General anti‐selectin therapy (fucoidan) or anti‐adhesion therapy with an antithrombin inhibitor (hirudin) was also used.

Corrections

Marina Berenguer, Martin Prieto, Fernando San Juan, José M. Rayón, Fernando Martinez, Domingo Carrasco, Angel Moya, Francisco Orbis, José Mir, Joaquín Berenguer – 30 December 2003

Subscribe to