A new step toward standardization of serum hepatitis C Virus–RNA quantification in patients with chronic hepatitis C

Michèle Martinot‐Peignoux, Nathalie Boyer, Véronique Le Breton, Gaëlle Le Guludec, Corinne Castelnau, Raoudha Akremi, Patrick Marcellin – 30 December 2003 – The need to improve efficacy of antiviral therapy for chronic hepatitis C has prompted the development of quantitative assays, which allows the assessment of viral load before therapy.

Fas‐ and tumor necrosis factor receptor 1–dependent but not perforin‐dependent pathways cause injury in livers infected with an adenovirus construct in mice

Zhang‐Xu Liu, Sugantha Govindarajan, Shigefumi Okamoto, Gunther Dennert – 30 December 2003 – Intravenous injection of type 5 adenovirus, deleted in the E1 and E3 regions, is shown to result in expression of viral antigens in the liver, initiating lymphocyte infiltration and liver injury. Following this infection, induction of Fas ligand (FasL), tumor necrosis factor α (TNF‐α), and perforin mRNA are all demonstrable in the liver, pointing to a role of respective pathways in liver injury.

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