Intentional coinfection of patients with HCV infection using avian infection bursal disease virus
Tibor Bakács, Jitendra N. Mehrishi – 30 December 2003
Lack of evidence for ribavirin‐induced bone loss
Andrea Trombetti, Emiliano Giostra, Gilles Mentha, Francesco Negro, Rene Rizzoli – 30 December 2003
Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver
Hajime Honda, Kenichi Ikejima, Miyoko Hirose, Mutsuko Yoshikawa, Tie Lang, Nobuyuki Enomoto, Tsuneo Kitamura, Yoshiyuki Takei, Nobuhiro Sato – 30 December 2003 – In this study, we investigated hepatic fibrogenesis caused by long‐term thioacetamide (TAA) administration in ob/ob mice, a naturally occurring leptin deficient animal. In the lean littermates, prominent hepatic fibrosis, as well as positive staining for α smooth muscle actin (α‐SMA), was induced by treatment with TAA (200 μg/g, IP, 3 times per week) for 4 to 8 weeks as expected.
Navajo neuropathy: Relation to MDR3 mRNA deficiency
Daniel Ortiz, Irwin M. Arias, Laura McKellar, Vincent P. Stanton – 30 December 2003
The effects of portal shunts on intestinal cytochrome P450 3A activity
Amin Rostami‐Hodjegan, Geoffrey T. Tucker – 30 December 2003
Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons
Cecília M. P. Rodrigues, Susana Solá, Dora Brites – 30 December 2003 – Increased levels of unconjugated bilirubin, the end‐product of heme catabolism, are detrimental to the central nervous system. To examine the role of apoptosis in bilirubin‐induced toxicity and to characterize the biochemical pathway of cell death, we exposed developing rat brain neurons to purified unconjugated bilirubin at concentrations below and above saturation of human serum albumin. Isolated neurons treated with bilirubin showed increased levels of apoptosis.
The allocation of livers for transplantation: A problem of Titanic consideration
Timothy L. Pruett – 30 December 2003
Dose‐dependent inhibition of hepatic fibrosis in mice by a TGF‐β soluble receptor: Implications for antifibrotic therapy
Yutaka Yata, Philip Gotwals, Victor Koteliansky, Don C. Rockey – 30 December 2003 – Transforming growth factor (TGF) β isoforms (in particular, TGF‐β1) play a central role in the fibrogenic response to injury in many organs, including the liver. Although TGF‐β is clearly important in fibrogenesis, a number of issues related to therapeutic antagonism have emerged. For example, the long‐term effect of TGF‐β antagonism is unknown; furthermore, controversy exists as to appropriate levels of TGF‐β inhibition.
Relationship between acetaldehyde levels and cell survival in ethanol‐metabolizing hepatoma cells
Dahn L. Clemens, Andrew Forman, Thomas R. Jerrells, Michael F. Sorrell, Dean J. Tuma – 30 December 2003 – We have created a number of recombinant Hep G2 cell lines, designated VA cells, that constitutively express alcohol dehydrogenase. Oxidation of ethanol by the VA cells results in the production and accumulation of acetaldehyde, and a dramatic increase in the nicotinamide adenine dinucleotide, reduced (NADH)/nicotinamide adenine dinucleotide (NAD+) ratio (redox‐state).
Liver transplantation as definitive therapy for complications after arterial embolization for hepatic manifestations of hereditary hemorrhagic telangiectasia
Jon S. Odorico,, M. Nawar Hakim, Yolanda T. Becker, Willem Van der Werf, Alexandru Musat, Stuart J. Knechtle, Anthony M. D'Alessandro, Munci Kalayoglu – 30 December 2003 – Experience with hepatic artery embolization for the treatment of symptomatic hepatic arteriovenous malformations (AVMs) in Rendu‐Osler‐Weber disease is limited. We report 2 cases of hepatic AVMs that caused mesenteric angina‐like symptoms that were treated with embolization.