R Blomhoff – 30 December 2003

D E Jones, J V Metcalf, J D Collier, M F Bassendine, O F James – 30 December 2003 – In this study we have determined the incidence of hepatocellular carcinoma (HCC) development in primary biliary cirrhosis (PBC) and its effects on patient survival. Six hundred and sixty seven patients with liver histology compatible with or diagnostic of PBC were seen over a 20‐year period.

L Marucci, L Varticovski, I M Arias – 30 December 2003 – Hepatocellular carcinoma (HCC) frequently overexpresses the MDR1 gene and is resistant to drugs transported by the multidrug‐resistance efflux pump. A xanthine analog, 1‐(11‐dodecylamino‐10‐hydroxyundecyl)‐ 3,7‐dimethylxanthine (CT‐2584,CTI), is cytotoxic to many tumors in culture and was four times more effective than verapamil in inhibiting Rhodamine 123 secretion in MDR1‐overexpressing Chinese hamster ovary cells.

R Lenzen, J Elster, C Behrend, K Hampel, W Bechstein, P Neuhaus – 30 December 2003 – The present study characterizes recovery of bile secretion after orthotopic liver transplantation (OLT) in humans with special regard to hormonal regulation of bile acid‐independent bile flow by glucagon and secretin. Sixty‐seven patients with an uncomplicated postoperative course were studied during the first 3 weeks after OLT to determine normalization of bile flow.

I H McKillop, C M Schmidt, P A Cahill, J V Sitzmann – 30 December 2003 – The mitogen‐activated protein kinase (MAPK) cascade acts as a focal point for signal transduction following activation of both G‐protein‐linked and tyrosine kinase growth factor receptors. A common intermediate between both of these diverse receptor subtypes includes the small guanosine triphosphate (GTP)‐binding protein, p21ras.

T Kawamura, S Toyabe, T Moroda, T Iiai, H Takahashi‐Iwanaga, M Fukada, H Watanabe, H Sekikawa, S Seki, T Abo – 30 December 2003 – In a recent series of studies, we demonstrated that stress in humans and animals, with resultant sympathetic nerve strain, induces severe granulocytosis, because granulocytes carry adrenergic receptors on the surface. Because activated granulocytes produce free radicals and superoxides, they sometimes induce tissue damage if the stress is too strong or continuous. Human neonates are also known to show high levels of granulocytes in the peripheral blood.

W Block, C Reichel, F Traber, T Skodra, R Lamerichs, B Kreft, U Spengler, T Sauerbruch, H Schild – 30 December 2003 – Experimental and clinical studies have led to the hypothesis that the phosphodiester signal obtained by 31P magnetic resonance (MR) spectroscopy may be a specific marker for the hepatic induction of oxidative metabolism (P450 induction) by phenobarbitone or ethanol. Systematic studies in humans are lacking.

L Rabeneck – 30 December 2003

Adrian M Di Bisceglie – 30 December 2003 – Hepatitis C virus (HCV) infection is now recognized to be a major risk factor for hepatocellular carcinoma (HCC), evidenced by finding both antibody to HCV (anti‐HCV) and HCV RNA in serum of a substantial proportion of patients with HCC around the world and by the progression of liver disease to cirrhosis and HCC in individual patients infected with HCV. There seems to be an incubation period of two to three decades on average in most cases of HCV‐related HCC.

R L Carithers, S S Emerson – 30 December 2003 – We performed an independent meta‐analysis of all available randomized clinical trials of interferon alfa‐2b in patients with chronic hepatitis C. Articles published between 1986 and 1996 had to include previously untreated patients who were randomly allocated to therapy with at least 2 million units (MU) of interferon alfa‐2b three times weekly for 24 weeks. A total of 32 trials met the inclusion criteria.