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Naga Chalasani, J. Christopher Gorski, Nilesh H. Patel, Stephen D. Hall, Raymond E. Galinsky – 30 December 2003

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Christina Ziemann, Dirk Schäfer, Gudrun Rüdell, Jens G. Scharf, Georg F. Kahl, Karen I. Hirsch‐Ernst – 30 December 2003

Normal hepatocytes correct serum bilirubin after repopulation of Gunn rat liver subjected to irradiation/partial resection

Chandan Guha, Bhupesh Parashar, Niloy J. Deb, Madhur Garg, Giridhar R. Gorla, Anupam Singh, Namita Roy‐Chowdhury, Bhadrasain Vikram, Jayanta Roy‐Chowdhury – 30 December 2003 – The treatment of inherited metabolic liver diseases by hepatocyte transplantation (HT) would be greatly facilitated if the transplanted normal hepatocytes could be induced to proliferate preferentially over the host liver cells. We hypothesized that preparative hepatic irradiation (HIR) should inhibit host hepatocyte proliferation in response to partial hepatectomy (PH).

Preconditioning protects liver and lung damage in rat liver transplantation: Role of xanthine/xanthine oxidase

Leticia Fernández, Nicolás Heredia, Luis Grande, Gloria Gómez, Antonio Rimola, Alberto Marco, Emilio Gelpí, Joan Roselló‐Catafau, Carmen Peralta – 30 December 2003 – This study was designed to evaluate whether ischemic preconditioning could confer protection against liver and lung damage associated with liver transplantation. The effect of preconditioning on the xanthine/xanthine oxidase (XOD) system in liver grafts subjected to 8 and 16 hours of cold ischemia was also evaluated.

Regulation of endothelin‐A receptor sensitivity by cyclic adenosine monophosphate in rat hepatic stellate cells

Roland Reinehr, Richard Fischer, Dieter Häussinger – 30 December 2003 – Sensitization of the endothelin‐A receptor (ETA) occurs during HSC transdifferentiation, but the underlying mechanisms remained unclear. Sensitization of ETA was studied in quiescent and activated hepatic stellate cells (HSC) at the levels of receptor phosphorylation, localization, endothelin (ET)‐1‐induced Ca2+ signals, and cell contraction.

Increasing intra‐abdominal pressure increases pressure, volume, and wall tension in esophageal varices

Angels Escorsell, Angels Ginès, Josep Llach, Joan C. García‐Pagán, Josep M. Bordas, Jaume Bosch, Joan Rodés – 30 December 2003 – Many daily activities cause acute elevations of intra‐abdominal pressure (IAP). In portal hypertensive cirrhotic patients, increased IAP increases absolute portal pressure and azygos blood flow, suggesting that it may have detrimental consequences at the esophageal varices. The aim of this study was to investigate the effects of increased IAP on variceal pressure, size, and wall tension.

p53 gene and Wnt signaling in benign neoplasms: β‐catenin mutations in hepatic adenoma but not in focal nodular hyperplasia

Ya‐Wen Chen, Yung‐Ming Jeng, Shiou‐Hwei Yeh, Pei‐Jer Chen – 30 December 2003 – Hepatocellular adenoma (HA) and focal nodular hyperplasia (FNH) are 2 rare, benign liver neoplasms that often are discovered incidentally. To date, few genetic changes have been found in these 2 benign lesions. However, the 2 pathways of p53 and Wnt signaling, which may be the most common molecular targets involved in liver tumorgenesis, were studied in HA and FNH. Ten HAs and 11 FNHs were analyzed for loss of heterozygosity (LOH) and sequencing analysis of mutation hot spots in exons 5 to 8 of the p53 gene.

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