Hereditary hemochromatosis in liver transplantation

M. Isabel Fiel, Thomas D. Schiano, Henry C. Bodenheimer, Swan N. Thung, Thomas W. King, C. Rathna Varma, Charles M. Miller, Elizabeth M. Brunt, Steven Starnes, Cynthia Prass, Roger K. Wolff, Bruce R. Bacon – 30 December 2003 – A candidate gene, HFE, was recently described in patients with hereditary hemochromatosis (HH) and found to contain a missense mutation leading to a cysteine to tyrosine substitution (C282Y). A second mutation, H63D, was also found in the gene.

CD40L (CD154) expression in human liver allografts during chronic ductopenic rejection

Anderson S. Gaweco, Russell H. Wiesner, Sherri Yong, Ruud Krom, Michael Porayko, Gregorio Chejfec, Kenneth D. McClatchey – 30 December 2003 – The CD40‐CD40L (CD154) interaction plays a pivotal role in the effector mechanisms of allograft rejection. Blockade of the CD40/CD40L costimulatory pathway prevents the development of chronic allograft rejection in several animal transplant models. The relevance of in situ CD40 and CD40L expression in human liver allografts was assessed by immunohistochemistry during ductopenic chronic rejection (CR).

Post–liver transplantation myocardial dysfunction

Priya Sampathkumar, Amir Lerman, Barbara Youngmee Kim, Bradley J. Narr, John J. Poterucha, Laurence C. Torsher, David J. Plevak – 30 December 2003 – Patients with end‐stage liver disease usually show a hyperdynamic circulatory state. It has previously been reported that patients who develop myocardial depression in the early post–liver transplantation period are more prone to organ failure and death.

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