New ways of interfering with HCV replication
Peter Hasselblatt, Hubert E. Blum, Wolf‐Bernhard Offensperger – 30 December 2003 – RNA interference is a cellular process of gene silencing in which small duplexes of RNA specifically target a homologous sequence for cleavage by cellular ribonucleases. The introduction of approximately 22‐nt small interfering RNAs (siRNAs) into mammalian cells can specifically silence cellular mRNAs without induction of the nonspecific IFN responses that are activated by longer RNA duplexes.