Fetal microchimerisms in the mother: Immunologic implications

Atsushi Tanaka, Keith Lindor, Aftab Ansari, M. Eric Gershwin – 30 December 2003 – The previously held concept that the fetus is completely separated from the mother, especially by trophoblasts that line the outer layer of the placenta, has recently been questioned. It has recently been shown that fetal cells are detectable not only in the peripheral blood, but also in maternal skin and liver.

Around the world with the model for end‐stage liver disease

Richard B. Freeman – 30 December 2003 – Background: Indices for predicting survival are essential for assessing prognosis and assigning priority for liver transplantation in patients with liver cirrhosis. The model for end stage liver disease (MELD) has been proposed as a tool to predict mortality risk in cirrhotic patients. However, this model has not been validated beyond its original setting. Aim: To evaluate the short and medium term survival prognosis of a European series of cirrhotic patients by means of MELD compared with the Child‐Pugh score.

Cerebral glucose and oxygen metabolism in patients with fulminant hepatic failure

Gitte Irene Strauss, Kirsten Møller, Fin Stolze Larsen, Jens Kondrup, Gitte Moos Knudsen – 30 December 2003 – Hyperammonemia and hyperventilation are consistent findings in patients with fulminant hepatic failure (FHF), which may interfere with cerebral glucose and oxygen metabolism. The aim of the present study is to evaluate whether cerebral oxidative metabolism is preserved early in the course of FHF and whether hyperventilation has an influence on this. We included 16 patients with FHF, 5 patients with cirrhosis of the liver, and 8 healthy subjects.

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