Cytochrome P‐450 content and activity after cold storage of rat hepatocytes in university of wisconsin and sodium‐lactobionate‐sucrose solutions

Halima Serrar, Ayman El‐Kadi, Patrick Du Souich, Pierre Haddad – 30 December 2003 – We compared the capacity of University of Wisconsin (UW) and of sodium‐lactobionate‐sucrose (SLS) hypothermic preservation solutions to maintain the integrity of the hepatic cytochrome P‐450–dependent mono‐oxygenase system. Isolated rat hepatocytes were stored for 0, 10, 24, and 48 hours in UW or SLS solution and were subsequently cultured shortly at 37°C.

Acute liver failure associated with prolonged use of bromfenac leading to liver transplantation

Robert J. Fontana, Timothy M. McCashland, Kent G. Benner, Henry D. Appelman, Naresh T. Gunartanam, James L. Wisecarver, John M. Rabkin, William M. Lee, Acute Liver Failure Study Group – 30 December 2003 – Bromfenac, a nonnarcotic analgesic nonsteroidal anti‐inflammatory drug, was associated with reversible, minor elevations in serum aminotransferase levels during clinical trials.

The prediction of acute cellular rejection in orthotopic liver transplantation

Andrew J. Bathgate, Paula Hynd, David Sommerville, Peter C. Hayes – 30 December 2003 – The occurrence of acute cellular rejection after orthotopic liver transplantation is common. At present, no allowance is made in immunosuppressive regimens for parameters other than weight. We investigated parameters in 121 consecutive patients receiving their primary allograft to determine if there are pretransplantation factors predicting the occurrence of acute cellular rejection after transplantation.

Fetal microchimerisms in the mother: Immunologic implications

Atsushi Tanaka, Keith Lindor, Aftab Ansari, M. Eric Gershwin – 30 December 2003 – The previously held concept that the fetus is completely separated from the mother, especially by trophoblasts that line the outer layer of the placenta, has recently been questioned. It has recently been shown that fetal cells are detectable not only in the peripheral blood, but also in maternal skin and liver.

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