Acute liver failure associated with prolonged use of bromfenac leading to liver transplantation

Robert J. Fontana, Timothy M. McCashland, Kent G. Benner, Henry D. Appelman, Naresh T. Gunartanam, James L. Wisecarver, John M. Rabkin, William M. Lee, Acute Liver Failure Study Group – 30 December 2003 – Bromfenac, a nonnarcotic analgesic nonsteroidal anti‐inflammatory drug, was associated with reversible, minor elevations in serum aminotransferase levels during clinical trials.

The prediction of acute cellular rejection in orthotopic liver transplantation

Andrew J. Bathgate, Paula Hynd, David Sommerville, Peter C. Hayes – 30 December 2003 – The occurrence of acute cellular rejection after orthotopic liver transplantation is common. At present, no allowance is made in immunosuppressive regimens for parameters other than weight. We investigated parameters in 121 consecutive patients receiving their primary allograft to determine if there are pretransplantation factors predicting the occurrence of acute cellular rejection after transplantation.

Fetal microchimerisms in the mother: Immunologic implications

Atsushi Tanaka, Keith Lindor, Aftab Ansari, M. Eric Gershwin – 30 December 2003 – The previously held concept that the fetus is completely separated from the mother, especially by trophoblasts that line the outer layer of the placenta, has recently been questioned. It has recently been shown that fetal cells are detectable not only in the peripheral blood, but also in maternal skin and liver.

Around the world with the model for end‐stage liver disease

Richard B. Freeman – 30 December 2003 – Background: Indices for predicting survival are essential for assessing prognosis and assigning priority for liver transplantation in patients with liver cirrhosis. The model for end stage liver disease (MELD) has been proposed as a tool to predict mortality risk in cirrhotic patients. However, this model has not been validated beyond its original setting. Aim: To evaluate the short and medium term survival prognosis of a European series of cirrhotic patients by means of MELD compared with the Child‐Pugh score.

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