Ubiquitin‐mediated degradation of cellular proteins in health and disease
Aaron Ciechanover, Alan L. Schwartz – 30 December 2003
Promoter polymorphism of the CD14 endotoxin receptor gene and primary biliary cirrhosis
Christophe Corpechot, Raoul Poupon – 30 December 2003
Inhibition of internal ribosomal entry site–directed translation of HCV by recombinant IFN‐α correlates with a reduced La protein
Takeo Shimazaki, Masao Honda, Shuichi Kaneko, Kenichi Kobayashi – 30 December 2003 – Translation of the hepatitis C virus (HCV) polyprotein is mediated by an internal ribosome entry site (IRES) that is located within the 5′‐nontranslated region (5′NTR). We investigated the effect of interferon alfa (IFN‐α) on the IRES‐directed translation of HCV, using two stably transformed cell lines, RCF‐1 and RCF‐26, of Huh7 cells derived from human hepatocellular carcinoma that express dicistronic reporter proteins, Renilla luciferase (RL) and firefly luciferase (FL), separated by HCV‐IRES.
Is cerebral edema a component of the syndrome of hepatic encephalopathy?
E. Anthony Jones, Cristina Lavini – 30 December 2003
Ito becomes a star
Adrian Reuben – 30 December 2003
Hepatology highlights
Harvey J. Alter – 30 December 2003
Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver
Mark A. Ross, Christina M. Sander, Talia B. Kleeb, Simon C. Watkins, Donna Beer Stolz – 30 December 2003 – Regenerating liver was evaluated for the spatiotemporal expression of angiogenic growth factor receptors on endothelial cell (EC) membranes during revascularization resulting from 70% partial hepatectomy (PHx). Fractions enriched in EC membranes were examined by Western blot for angiogenic growth factor receptor expression from 1 to 14 days after PHx.
Towards a reliable parameter of liver damage in hepatitis C: TUNEL versus caspase activation
Young S. Hahn, Carolina Soguero, Michael Cruise – 30 December 2003
Defective mitogen‐activated protein kinase (ERK2) signaling in gastric mucosa of portal hypertensive rats: Potential therapeutic implications
Hirofumi Kawanaka, Morimasa Tomikawa, Michael K. Jones, Imre L. Szabo, Rama Pai, Dolgor Baatar, Kouji Tsugawa, Keizo Sugimachi, I. James Sarfeh, Andrzej S. Tarnawski – 30 December 2003 – Portal hypertensive (PHT) gastropathy is a frequent, serious complication of liver cirrhosis. PHT gastric mucosa has numerous abnormalities such as reduced mucosal potential differences, reduced surface oxygenation, and increased susceptibility to injury caused by alcohol, aspirin, and other noxious factors.
Adenosine reverses a preestablished CCl4‐induced micronodular cirrhosis through enhancing collagenolytic activity and stimulating hepatocyte cell proliferation in rats
Rolando Hernández‐Muñoz, Mauricio Díaz‐Muñoz, Juan A. Suárez‐Cuenca, Cristina Trejo‐Solís, Verónica López, Lourdes Sánchez‐Sevilla, Lucía Yáñez, Victoria Chagoya De Sánchez – 30 December 2003 – Cirrhosis is one of the most common causes of mortality worldwide, because hepatic dysfunction constitutes a potentially lethal condition. Having demonstrated the hepatoprotective effect of adenosine against CCl4‐induced cirrhosis, the present study was aimed at assessing adenosine's effect on an already‐established micronodular cirrhosis.