Identification of B10, an alkaline phosphodiesterase of the apical plasma membrane of hepatocytes and biliary cells, in rat serum: Increased levels following bile duct ligation and during the development of cholangiocarcinoma

Nirina Rajho Meerson, Danièle Delautier, Anne‐Marie Durand‐Schneider, Alain Moreau, Michael L. Schilsky, Irmin Sternlieb, Gérard Feldmann, Michèle Maurice – 30 December 2003 – Alkaline phosphodiesterase (APDE) is associated with the cellular plasma membrane of many organs. Several isoforms are also detected in normal human serum and their respective amounts vary in liver diseases but their significance is unknown.

Inhibition of leukocyte adherence and transendothelial migration in cultured human liver vascular endothelial cells by prostaglandin E1

Jinning Lou, Leo Bühler, Shaoping Deng, Gilles Mentha, Roberto Montesano, Georges E. Grau, Philippe Morel – 30 December 2003 – Primary graft dysfunction is a major complication of orthotopic liver transplantation, and hepatic ischemic reperfusion injury is considered to be its major determinant cause. Although oxygen free radicals play an important role, leukocytes, cytokines, and adhesion molecules also contribute to hepatic ischemic reperfusion injury.

Serum immunoglobulin M antibody to hepatitis D as a surrogate marker of hepatitis D in interferon‐treated patients and in patients who underwent liver transplantation

Elisabetta Borghesio, Floriano Rosina, Antonina Smedile, Marco Lagget, Maria Grazia Niro, Giovanni Marinucci, Mario Rizzetto – 30 December 2003 – The kinetics of the immunoglobulin (Ig) M type antibody to the hepatitis D virus (IgM anti‐HD) were investigated in hepatitis B surface antigen (HBsAg) carriers with chronic hepatitis D treated with interferon (IFN) and in patients with terminal hepatitis delta virus (HDV) cirrhosis who underwent liver transplantation.

Expression of hepatitis B virus X protein in HBV‐infected human livers and hepatocellular carcinomas

Qin Su, Claus H. Schröder, Walter J. Hofmann, Gerd Otto, Rudolf Pichlmayr, Peter Bannasch – 30 December 2003 – Transactivation of cellular genes and functional inactivation of p53 by the hepatitis B virus (HBV) X gene‐encoded protein (HBx) are proposed as alternative mechanisms for induction of hepatocellular carcinomas (HCCs) in chronic HBV infection. Using an immunohistochemical approach, we studied the expression of HBx in 39 explanted livers with HBV‐associated disease.

Re‐treatment with interferon alfa of patients with chronic hepatitis C

Wan‐Cheng Chow, Nathalie Boyer, Michele Pouteau, Corinne Castelnau, Michele Martinot‐Peignoux, Veronique Martins‐Amado, Francoise Degos, Crina Maghinici, Martine Sinegre, Jean‐Pierre Benhamou, Claude Degott, Serge Erlinger, Patrick Marcellin – 30 December 2003 – Treatment of patients with chronic hepatitis C has had limited success because of relapses and nonresponse to interferon alfa therapy (currently the only established therapeutic agent).

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