Hepatology highlights
Elwyn Elias – 30 December 2003
Pivotal role of G‐protein–coupled adenosine A2a receptors in protection of the liver against inflammation and ischemia‐reperfusion injury
Manfred Bilzer, Alexander L. Gerbes – 30 December 2003
Hepatitis C research
30 December 2003
Chopin's serpin
Adrian Reuben – 30 December 2003
Hepatology highlights
Elwyn Elias – 30 December 2003
New ways of interfering with HCV replication
Peter Hasselblatt, Hubert E. Blum, Wolf‐Bernhard Offensperger – 30 December 2003 – RNA interference is a cellular process of gene silencing in which small duplexes of RNA specifically target a homologous sequence for cleavage by cellular ribonucleases. The introduction of approximately 22‐nt small interfering RNAs (siRNAs) into mammalian cells can specifically silence cellular mRNAs without induction of the nonspecific IFN responses that are activated by longer RNA duplexes.
Expression of MUC1 and MUC2 mucin antigens in intrahepatic bile duct tumors: Its relationship with a new morphological classification of cholangiocarcinoma
Michiyo Higashi, Suguru Yonezawa, Jenny J. L. Ho, Sadao Tanaka, Tatsuro Irimura, Young S. Kim, Eiichi Sato – 30 December 2003 – Our previous immunohistochemical study on intrahepatic bile duct tumors showed that invasive cholangiocarcinoma (ICC) with a poor outcome expressed MUC1 mucin but was negative for MUC2 mucin, whereas bile duct cystadenocarcinoma (BDCC) with a favorable outcome was MUC1 negative and MUC2 positive. In the present study, ICC was further subdivided into 2 subtypes: intraductal growth type and/or periductal infiltrating type (ICC‐IP) and mass forming type (ICC‐M).
Phase I and Phase II drug‐metabolizing enzymes are expressed and heterogeneously distributed in the biliary epithelium
Fatima Lakehal, Dominique Wendum, Véronique Barbu, Laurent Becquemont, Raoul Poupon, Pierre Balladur, Laurent Hannoun, François Ballet, Philippe H. Beaune, Chantal Housset – 30 December 2003 – Tissue expression of drug‐metabolizing enzymes influences susceptibility to drugs and carcinogens. Because the biliary epithelium, exposed to bile‐borne chemicals, may give rise to drug‐induced cholangiopathies and to cholangiocarcinomas, we determined the pattern of expression of drug‐metabolizing enzymes in this epithelium.