Chang Han, A. Jake Demetris, George K. Michalopoulos, Qimin Zhan, James H. Shelhamer, Tong Wu – 30 December 2003 – Ligands of peroxisome proliferator‐activated receptor‐γ (PPARγ) induce differentiation and growth inhibition in several human cancers. However, the role of PPARγ ligands in the growth control of human cholangiocarcinoma cells remains unknown. This study was designed to investigate the biological functions and molecular mechanisms of PPARγ ligands in the growth regulation of human cholangiocarcinoma cells.

Carlo Giannini, Serban Morosan, J. Guilherme Tralhao, Jacques Emmanuel Guidotti, Serena Battaglia, Karine Mollier, Laurent Hannoun, Dina Kremsdorf, Helene Gilgenkrantz, Pierre Charneau – 30 December 2003 – Allogenic hepatocyte transplantation or autologous transplantation of genetically modified hepatocytes has been used successfully to correct congenital or acquired liver diseases and can be considered as an alternative to orthotopic liver transplantation.

Paul D. Berk – 30 December 2003

Nasir Khokhar, Naila Asif, Omar S. Khokhar – 30 December 2003

Steven W. M. Olde Damink, Nicolaas E. P. Deutz, Peter B. Soeters, Rajiv Jalan – 30 December 2003

Oscar Escribano, María Dolores Fernández‐Moreno, José Antonio Zueco, Cesar Menor, Jesus Fueyo, Rosa María Ropero, Inés Diaz‐Laviada, Irene D. Román, Luis G. Guijarro – 30 December 2003 – This study was designed to characterize insulin receptor substrate‐4 (IRS‐4) in isolated rat hepatocytes and to examine its role in liver regeneration. Subcellular fractionation revealed that 85% of IRS‐4 is located at isolated hepatocyte plasma membranes. The distribution of IRS‐4 among intracellular compartments remained unchanged in insulin‐stimulated cells.

Mylène Sebagh, Kinan Rifai, Cyrille Féray, Funda Yilmaz, Bruno Falissard, Bruno Roche, Henri Bismuth, Didier Samuel, Michel Reynès – 30 December 2003 – The value of late protocol biopsies after liver transplantation remains to be evaluated to highlight the therapeutic policies. The study population was composed of patients who survived with the initial graft and with an available 10‐year protocol biopsy (n = 143).

Alejandro Soza, Jay H. Hoofnagle – 30 December 2003

Hironori Koga, Masaru Harada, Motoaki Ohtsubo, Shoichiro Shishido, Hiroto Kumemura, Shinichiro Hanada, Eitaro Taniguchi, Katsumi Yamashita, Ryukichi Kumashiro, Takato Ueno, Michio Sata – 30 December 2003 – Increasing evidence has confirmed that ligands for peroxisome proliferator‐activated receptor γ (PPARγ) exhibit antitumoral effects through inhibition of cell proliferation and induction of cell differentiation in several malignant neoplasms.

Reem Ghalib, Cheryl Levine, Manal Hassan, Tricia McClelland, John Goss, Risë Stribling, Philip Seu, Yehuda Z. Patt – 30 December 2003 – To elucidate the hematopoietic activity of recombinant human interleukin‐11 (rhIL‐11, [Neumega, Cambridge, MA]) in patients with cirrhosis and thrombocytopenia, we administered rhIL‐11 at 50 μg/kg/d subcutaneously to 10 patients for 10 days with a 30‐day follow‐up period.