David J. Woollard, Arash Grakoui, Naglaa H. Shoukry, Krishna K. Murthy, Katherine J. Campbell, Christopher M. Walker – 30 December 2003 – Resolution of hepatitis C virus (HCV) infection is associated with strong and sustained virus‐specific CD4+ T cell responses. In this study, we investigated the evolution of functional T cell responses during acute infection of a chimpanzee and the longevity of these lymphocytes in blood and liver after resolution of infection.

Samuel S. Lee – 30 December 2003

Steven‐Huy B. Han, Joshua Ofman, Curtis Holt, Kevin King, Gregg Kunder, Pauline Chen, Sherfield Dawson, Leonard Goldstein, Hasan Yersiz, Douglas G. Farmer, Rafik M. Ghobrial, Ronald W. Busuttil, Paul Martin – 30 December 2003 – Orthotopic liver transplantation (OLT) for hepatitis B virus (HBV) infection was limited until recently by poor graft and patient outcomes caused by recurrent HBV. Long‐term immunoprophylaxis with hepatitis B immune globulin (HBIG) dramatically improved post‐OLT survival, but recurrent HBV still occurred in up to 36% of the recipients.

Robert S. Brown – 30 December 2003

A. B. van As, Z. Lotz, M. Tyler, D. Kahn – 30 December 2003 – The conventional technique of liver transplantation involves the initial perfusion of the graft with portal blood. However, recent evidence suggests that initial arterialization of the graft may be better. The aim of this study is to evaluate the timing of arterialization on reperfusion injury, hepatocellular injury, and endothelial cell function after liver transplantation. Large white X Landrace pigs (n = 24) were subjected to orthotopic liver transplantation.

Sanjiv Saigal, Suzanne Norris, Parthi Srinivasan, Paolo Muiesan, Mohamed Rela, Nigel Heaton, John O'Grady – 30 December 2003 – Preexisting malignancy is considered a relative contraindication to orthotopic liver transplantation (OLT) because of the risk of tumor recurrence. The purpose of this study is to assess the outcome of OLT in patients with a preexistent malignant state.

Cosme Manzarbeitia, David J. Reich, Kenneth D. Rothstein, Leonard E. Braitman, Scott Levin, Santiago J. Munoz – 30 December 2003 – With improvements in surgical technique and the advent of new and more effective immunosuppressive agents, survival rates in liver transplant recipients have dramatically improved. However, hyperlipidemia frequently develops in patients administered cyclosporine‐based immunosuppression long‐term, although it appears to occur less often with newer, tacrolimus‐based regimens.

Parthi Srinivasan, Matthew J. Bowles, Paolo Muiesan, Nigel D. Heaton, Mohamed Rela – 30 December 2003 – The success of the triangulation technique for hepatic venous anastomosis in left lateral segment liver transplantation has led to standardization of this procedure. We report a case of syndromic biliary atresia with absent inferior vena cava in which we constructed a neo cava to implant a living related left lateral segment graft by using the triangulation technique.

Gitte Irene Strauss, Kirsten Møller, Søren Holm, Bjørn Sperling, Gitte Moos Knudsen, Fin Stolze Larsen – 30 December 2003 – Mechanical hyperventilation is often used to postpone or ameliorate intracranial hypertension in patients with fulminant hepatic failure (FHF). Because such treatment may critically reduce cerebral blood flow (CBF), bedside techniques to monitor CBF are warranted.

Stefan G. Hübscher – 30 December 2003 – Approximately 20% to 30% of patients undergoing liver transplantation for autoimmune hepatitis (AIH) develop features of recurrent disease. Diagnostic criteria for recurrent AIH are similar to those used in the nontransplanted liver and include, in varying combinations, biochemical, serological, and histological abnormalities and steroid dependency.