Influence of human fulminant hepatic failure sera on endogenous retroviral expression in pig hepatocytes

Scott L. Nyberg, Jonathan R. Hibbs, Joseph A. Hardin, Jeffrey J. Germer, Jeffrey L. Platt, Carlos V. Paya, Russell H. Wiesner – 30 December 2003 – A porcine endogenous retrovirus (PERV) has been shown to infect human embryonic kidney 293 (HEK293) cells in vitro. The PERV proviral sequence exists in the genome of all porcine cells, including hepatocytes used in a bioartificial liver (BAL). We examined the possibility of PERV infection in HEK293 cells during exposure to supernatant from cultured pig hepatocytes.

Predicting bacteremia and bacteremic mortality in liver transplant recipients

Nina Singh, David L. Paterson, Timothy Gayowski, Marilyn M. Wagener, Ignazio R. Marino – 30 December 2003 – Predictors of bacteremia and mortality in bacteremic liver transplant recipients were prospectively assessed. One hundred eleven consecutive episodes of fever or infections were documented in 59 patients over a 4‐year period. Forty‐nine percent (29 of 59 patients) of the patients had bacteremia, 39% (23 of 59 patients) had nonbacteremic infections, and 12% (7 of 59 patients) had fever of noninfectious cause.

Hepatic resection of noncolorectal nonneuroendocrine metastases

Alan W. Hemming, Tim D. Sielaff, Steven Gallinger, Mark S. Cattral, Bryce R. Taylor, Paul D. Greig, Bernard Langer – 30 December 2003 – Because hepatic resection is generally a safe procedure, the indications for resection of noncolorectal nonneuroendocrine (NCNNE) hepatic metastases have broadened. The prognostic features of NCNNE metastases treated surgically were reviewed to define better the value of resection. A retrospective review of patients undergoing liver resection for NCNNE metastases between 1978 and 1998 was undertaken. Thirty‐seven patients were identified.

Results of choledochojejunostomy in the treatment of biliary complications after liver transplantation in the era of nonsurgical therapies

Brian R. Davidson, Rakesh Rai, Ashim Nandy, Nilesh Doctor, Andrew Burroughs, Keith Rolles – 30 December 2003 – Advances in radiological and endoscopic techniques have allowed many biliary complications after orthotopic liver transplantation (OLT) to be managed without surgery. The influence of nonsurgical management on the outcome of patients requiring surgical revision has not been addressed. We reviewed our 10‐year experience (October 1988 to January 1998) of Roux‐en‐Y choledochojejunostomy (CDJ) to treat biliary complications after OLT.

Adult living donor transplants‐which portion of the liver to use?

Abhi Humar – 30 December 2003 – Hypothesis: Few studies have investigated the results of research focused on living donor adult liver transplantation. Different characteristics between right‐ and left‐lobe grafts have not yet been clarified in living‐donor adult liver transplantation. Left‐lobe grafts remain an important option, even in adult recipients. Setting: A single liver transplant center with a long history of hepatic resection. Patients: Forty‐five donors received left‐lobe (n = 39) and right‐lobe (n = 6) grafts.

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