Influence of human fulminant hepatic failure sera on endogenous retroviral expression in pig hepatocytes
Scott L. Nyberg, Jonathan R. Hibbs, Joseph A. Hardin, Jeffrey J. Germer, Jeffrey L. Platt, Carlos V. Paya, Russell H. Wiesner – 30 December 2003 – A porcine endogenous retrovirus (PERV) has been shown to infect human embryonic kidney 293 (HEK293) cells in vitro. The PERV proviral sequence exists in the genome of all porcine cells, including hepatocytes used in a bioartificial liver (BAL). We examined the possibility of PERV infection in HEK293 cells during exposure to supernatant from cultured pig hepatocytes.