Ai‐Min Hui, Xin Li, Ya‐Zhou Shi, Guido Torzilli, Tadatoshi Takayama, Masatoshi Makuuchi – 30 December 2003 – p27Kip1 is a cyclin‐dependent kinase inhibitor that negatively regulates cell proliferation. This study was designed to evaluate the roles of p27Kip1 in gallbladder carcinogenesis and the prognostic value of p27Kip1 in patients with gallbladder carcinoma. p27Kip1 expression was examined immunohistochemically in surgically resected specimens of 8 normal epithelia, 8 adenomyomatosis lesions, 6 precancerous adenomas, and 37 carcinomas of the gallbladder.

René Adam, Paul McMaster, John G. O'Grady, Denis Castaing, Jurgen L. Klempnauer, Neville Jamieson, Peter Neuhaus, Jan Lerut, Mauro Salizzoni, Stephen Pollard, Ferdinand Muhlbacher, Xavier Rogiers, Juan Carlos Garcia Valdecasas, Joaquin Berenguer, Daniel Jaeck, Enrique Moreno Gonzalez – 30 December 2003 – The European Liver Transplant Registry (ELTR) currently allows for the analysis of 44,286 liver transplantations (LTs) performed on 39,196 patients in a 13‐year period. After an exponential increase, the number of LTs is plateauing due to a lack of organs.

Markus H. Heim – 30 December 2003

Fabien Zoulim – 30 December 2003

Javier Vaquer, Queralt Jordano, William M. Lee, Andres T. Blei – 30 December 2003

Michael B. Ishitani – 30 December 2003 – Background Pediatric orthotopic liver transplantation (OLT) has a low mortality. Some children, however, have an adverse outcome defined as a prolonged ventilatory support requirement and protracted pediatric intensive care unit (PICU) stay. The aim of this study was to determine if that adverse outcome related to the child's condition pre‐OLT and/or the development of a pleural effusion or diaphragmatic dysfunction. Methods The study included 210 children with a median age at transplantation of 45.5 months (range 0.2‐252 months).

30 December 2003

30 December 2003

Jeffrey L. Platt – 30 December 2003

Isabel Cirera, Miguel Navasa, Antoni Rimola, Juan Carlos García‐Pagán, Luis Grande, Juan Carlos Garcia‐Valdecasas, Josep Fuster, Jaime Bosch, Juan Rodes – 30 December 2003 – Massive ascites after liver transplantation, although uncommon, usually represents a serious adverse event. The pathogenesis of this complication has not been adequately investigated. To determine the incidence, characteristics, and pathogenic factors of massive ascites after liver transplantation (ascitic fluid > 500 mL/d for >10 days), the charts of 378 liver transplant recipients were reviewed.