Helmut M. Diepolder, Norbert H. Gruener, Jonathan Heeney – 30 December 2003 – To define the early events that determine the outcome of acute hepatitis C virus (HCV) infection, we compared the course of viremia with the peripheral and intrahepatic T cell response and intrahepatic cytokine profile in six acutely infected chimpanzees. Three different outcomes were observed after peak viral titers were reached: sustained viral clearance, transient viral clearance followed by chronic infection, and chronic infection that persisted at initial peak titers.

Harvey J. Alter – 30 December 2003

30 December 2003

Marina Berenguer, Martin Prieto, Fernando San Juan, José M. Rayón, Fernando Martinez, Domingo Carrasco, Angel Moya, Francisco Orbis, José Mir, Joaquín Berenguer – 30 December 2003

30 December 2003

Hartmut Jaeschke – 30 December 2003 – Evidence shows that leukocyte recruitment into inflamed liver sinusoids does not require selectins, with one notable exception: ischemia‐reperfusion (I/R). We used intravital microscopy to directly visualize the liver microcirculation during I/R and localized endotoxemia (liver superfused with lipopolysaccharide). General anti‐selectin therapy (fucoidan) or anti‐adhesion therapy with an antithrombin inhibitor (hirudin) was also used.

Andreas Cerny – 30 December 2003

Neil Kaplowitz – 30 December 2003

30 December 2003

Thomas F. Imperiale, Naga Chalasani – 30 December 2003