Reverse transcriptase‐polymerase chain reaction fails to detect peripheral‐blood hepatitis C RNA in formalin‐fixed liver tissue

Rubén Bonilla Guerrero, Kenneth P. Batts, Jeffrey J. Germer, Rogelio G. Perez, Russell H. Wiesner, David H. Persing – 30 December 2003 – Currently, one of the major indications for liver transplantation is infection with hepatitis C virus (HCV). Many studies have suggested that recurrent infection with HCV is universal after transplantation. Fastidious techniques, such as reverse transcriptase‐polymerase chain reaction (RT‐PCR), have proved to be highly sensitive for detecting HCV RNA in serum and in fresh‐frozen and formalin‐fixed paraffin‐embedded (FFPE) liver tissue.

Hepatitis after liver transplantation: The role of the known and unknown viruses

Mario G. Pessoa, Norah A. Terrault, Linda D. Ferrell, Jill Detmer, Janice Kolberg, Mark L. Collins, Maurene Viele, John R. Lake, John P. Roberts, Nancy L. Ascher, Teresa L. Wright, – 30 December 2003 – This study was designed to determine the cause of posttransplantation hepatitis in patients undergoing transplantation for liver disease of nonviral cause; the role of acquired hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis G virus (HGV) in posttransplantation hepatitis; and the course of posttransplantation hepatitis of unknown cause.

Fulminant hepatic failure secondary to herpes simplex virus infection in a neonate: A case report of successful treatment with liver transplantation and perioperative acyclovir

Hiroto Egawa,, Yukihiro Inomata, Shingo Nakayama, Akira Matsui, Hirohiko Yamabe, Shinji Uemoto, Katsuhiro Asonuma, Koichi Tanaka – 30 December 2003 – Neonatal disseminated herpes simplex virus (HSV) infection, including fulminant hepatic failure (FHF), is lethal, and the patients rarely have a chance for liver transplantation because of the rapid development of the disease. We describe of a case of FHF secondary to HSV infection in a neonate successfully treated by aggressive intensive care followed by liver transplantation.

An appraisal of percutaneous treatment of liver metastases

Alighieri Mazziotti, Gian Luca Grazi, Andrea Gardini, Matteo Cescon, Filippo Pierangeli, Giorgio Ercolani, Elio Jovine, Antonino Cavallari – 30 December 2003 – Percutaneous treatments, such as ethanol injection and radiofrequency, have been recently proposed for the treatment of liver metastases. The aim of this study was to evaluate the effects of these treatments in a series of 8 patients who subsequently underwent liver resection. These patients had been treated with percutaneous methods between December 1995 and May 1997.

Weight change and obesity after liver transplantation: Incidence and risk factors

James E. Everhart,, Manuel Lombardero, John R. Lake, Russell H. Wiesner, Rowen K. Zetterman, Jay H. Hoofnagle – 30 December 2003 – Obesity is a concern in the long‐term management of patients following liver transplantation, yet the risk of obesity and the factors that influence its development have not been well defined. We evaluated posttransplantation weight change among a cohort of 774 adults who had their height and weight recorded before liver transplantation at three major centers. Obesity was defined as a body mass index (BMI) of at least 30 kg/m2.

Inflammatory process complicating giant hemangioma of the liver: Report of three cases

Bernard Pol, Patrick Disdier, Y. Patrice Treut,, Pierre Campan, Jean Hardwigsen, Pierre J. Weiller – 30 December 2003 – Three cases of giant hemangioma of the liver associated with clinical and laboratory signs of inflammatory process, including low‐grade fever, weight loss, abdominal pain, accelerated erythrocyte sedimentation rate, anemia, thrombocytosis, and increased fibrinogen level with normal white blood cell count are described.

Changes in peripheral blood double‐negative T‐lymphocyte (CD3+ CD4− CD8−) populations associated with acute cellular rejection after liver transplantation

Orla M. Crosbie, Patrick J. Costello, Cliona O'Farrelly, John E. Hegarty – 30 December 2003 – Circulating CD3+ T lymphocytes that express neither the CD4 nor CD8 surface molecules (double‐negative T lymphocytes) are phenotypically and functionally distinct from single‐positive CD3+CD4+ and CD3+CD8+ lymphocytes and are thought to represent a distinct T‐cell lineage.

Successful treatment of mycotic hepatic artery pseudoaneurysms with arterial reconstruction and liposomal amphotericin B

Steven M. Rudich, Milan M. Kinkhabwala, Natalie G. Murray, Darryl M. See, Ronald W. Busuttil, David K. Imagawa – 30 December 2003 – A 55‐year‐old woman developed end‐stage liver disease and the hepatorenal syndrome secondary to cryptogenic cirrhosis. Orthotopic liver transplantation was complicated by bile peritonitis, requiring reoperation and eventual placement of an internal biliary stent. On postoperative day 26, hemobilia was caused by localized rupture of mycotic (Aspergillus fumigatus) hepatic artery pseudoaneurysms with fistulization into the biliary tree.

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