Scott Nyberg – 30 December 2003

Shawn J. Pelletier, Julia C. Iezzoni, Traves D. Crabtree, Young S. Hahn, Robert G. Sawyer, Timothy L. Pruett – 30 December 2003 – Recurrence of hepatitis C virus (HCV) after orthotopic liver transplantation (OLT) remains a significant source of morbidity and mortality. Factors that reliably predict allograft injury from HCV have not been identified. Demographics, clinical data, and histopathological characteristics of recipients with and without persistently elevated serum transaminase levels (PEST) were compared.

Bijan Eghtesad, Nosrat Nezakatgoo, Lynda C. Geraci, Nicolas Jabbour, William D. Irish, Wallis Marsh, John J. Fung, Jorge Rakela – 30 December 2003 – Wilson's disease is a hereditary defect in copper excretion leading to the accumulation of copper in the tissues, with subsequent tissue damage. The most serious sequela is that of progressive central nervous system involvement. The use of orthotopic liver transplantation (OLT) has been controversial for those patients with neurological symptoms attributed to Wilson's disease.

Emilio Fábrega, Javier Crespo, Fernando Casafont, Joaquin de la Peña, Maria Teresa García‐Unzueta, Jose Antonio Amado, Fernando Pons‐Romero – 30 December 2003 – Adrenomedullin (AM) is a potent vasodilating peptide that increases rat platelet cyclic adenosine monophosphate levels and acts on endothelial cells to stimulate nitric oxide release. Both mechanisms inhibit platelet function. Considering these effects, AM may have a role in cardiovascular regulation after orthotopic liver transplantation (OLT) and could have an antithrombotic effect.

Steven M. Strasberg, Jeffrey A. Lowell, Todd K. Howard – 30 December 2003 – This article examines the scientific, technical, and administrative barriers to splitting donor livers for use in two adults. The main scientific barrier is that cadaveric donor livers at their current level of postoperative function are not sufficiently large to support life in two adult recipients. However, glycogenation of livers from young donors may be a method to overcome this problem in the short term.

M. Susan Mandell, Thomas Henthorn – 30 December 2003

William L. Lanier – 30 December 2003

William T. Merritt – 30 December 2003

Moni Stein, Steven M. Rudich, Jonathan L. Riegler, Richard V. Perez, Daniel P. Link, John P. McVicar – 30 December 2003 – Hepatic artery thrombosis remains one of the most serious complications after orthotopic liver transplantation. Sepsis, biliary leakage and strictures, and retransplantation are often the result of this devastating complication. Because retransplantation or reoperation is sometimes not possible or advisable, other means of reestablishing hepatic artery continuity are desirable.

Rubén Bonilla Guerrero, Kenneth P. Batts, Jeffrey J. Germer, Rogelio G. Perez, Russell H. Wiesner, David H. Persing – 30 December 2003 – Currently, one of the major indications for liver transplantation is infection with hepatitis C virus (HCV). Many studies have suggested that recurrent infection with HCV is universal after transplantation. Fastidious techniques, such as reverse transcriptase‐polymerase chain reaction (RT‐PCR), have proved to be highly sensitive for detecting HCV RNA in serum and in fresh‐frozen and formalin‐fixed paraffin‐embedded (FFPE) liver tissue.