Domino split‐liver transplantation from a living donor: Case reports of in situ and ex situ splitting

Yukihiro Inomata, Taro Nakamura, Shinji Uemoto, Koichi Tanaka, Go Wakabayashi, Motohide Shimazu – 30 December 2003 – The liver from a patient with familial amyloid polyneuropathy (FAP) scheduled for living donor liver transplantation can be split and transplanted into 2 adult patients with end‐stage liver disease. We have performed this procedure, called domino split transplantation, twice. The native liver was split in situ in 1 patient with FAP and ex situ in the other patient with FAP.

Acute changes in cerebral blood flow and metabolism during portasystemic shunting

Rajiv Jalan, David E. Newby, Steven W.M. Olde Damink, Doris N. Redhead, Peter C. Hayes, Alistair Lee – 30 December 2003 – This report describes the instantaneous changes in cerebral blood flow (CBF), determined by intravascular ultrasound and Doppler, in a patient with cirrhosis undergoing placement of a transjugular intrahepatic stent‐shunt for uncontrolled variceal bleeding. Acute changes in CBF were observed during and after portasystemic shunting, which culminated in cerebral edema and cerebral herniation.

Fitness testing of pediatric liver transplant recipients

Viswanath B. Unnithan, Suzanne H.E. Veehof, Philip Rosenthal, Christine Mudge, Teresa H. O'Brien, Patricia Painter – 30 December 2003 – Liver transplantation is accepted as the standard management for end‐stage liver disease in children. Pediatric heart and heart‐lung transplant recipients have shown significantly diminished exercise capacities compared with age‐matched, able‐bodied, control subjects.

Role of cytokine gene polymorphisms in acute rejection and renal impairment after liver transplantation

Julie R. Jonsson, Cui Hong, David M. Purdie, Carmel Hawley, Nicky Isbel, Maree Butler, Glenda A. Balderson, Andrew D. Clouston, Nirmala Pandeya, Katherine Stuart, Catherine Edwards‐Smith, Darrell H. Crawford, Jonathon Fawcett, Elizabeth E. Powell – 30 December 2003 – Although immunosuppressive regimens are effective, rejection occurs in up to 50% of patients after orthotopic liver transplantation (OLT), and there is concern about side effects from long‐term therapy.

Very early tracheal extubation without predetermined criteria in a liver transplant recipient population

Gianni Biancofiore, Anna Maria Romanelli, Maria L. Bindi, Giovanni Consani, Antonella Boldrini, Michele Battistini, Franco Filipponi, Franco Mosca, Antonio Vagelli – 30 December 2003 – This study of all patients undergoing orthotopic liver transplantation (OLT) at our center between January 1997 and December 1999 evaluated the feasibility and safety of very early tracheal extubation without previous selection.

Beneficial effects of converting liver transplant recipients from cyclosporine to tacrolimus on blood pressure, serum lipids, and weight

David A.J. Neal, Alexander E.S. Gimson, Paul Gibbs, Graeme J.M. Alexander – 30 December 2003 – Hypertension and hyperlipidemia are more prevalent after liver transplantation with cyclosporine as the primary immunosuppressive agent compared with tacrolimus. To determine whether blood pressure, serum lipid level, or weight improves when patients switch immunosuppression therapy, we retrospectively studied 26 liver transplant recipients with stable graft function who had been converted from cyclosporine to tacrolimus therapy with a median follow‐up of 8 months.

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