30 December 2003

E B Haagsma, G P Smit, K E Niezen‐Koning, A S Gouw, L Meerman, M J Slooff – 30 December 2003 – Type III glycogen storage disease (GSD) is a disorder of carbohydrate metabolism caused by a deficiency of debranching enzyme. Different subtypes with different clinical pictures have been recognized. During childhood and early adulthood, the symptoms generally regress, and normal adulthood appears possible in most patients without symptoms or signs of cirrhosis. We report on an adult patient with GSD who developed endstage cirrhosis and a small hepatocellular carcinoma.

Henrik Toft Sørensen, Søren Friis, Jørgen H. Olsen, Ane Marie Thulstrup, Lene Mellemkjær, Martha Linet, Dimitrios Trichopoulos, Hendrik Vilstrup, Jørn Olsen – 30 December 2003 – Cancer risk in patients with cirrhosis could be modified by factors such as changes in hormonal levels, impaired metabolism of carcinogens, or alteration of immunological status. We investigated the risk of liver and various forms of cancer in patients with cirrhosis in a follow‐up study.

Koert P. De Jong, Rudi Stellema, Arend Karrenbeld, Jan Koudstaal, Annette S. Gouw, Wim J. Sluiter, Paul M. J. G. Peeters, Maarten J. H. Slooff, Elisabeth G. E. De Vries – 30 December 2003 – To determine whether the expression of transforming growth factor α (TGF‐α), its receptor (epidermal growth factor receptor [EGFr]), p53 nuclear protein, and proliferation influences prognosis of patients with liver metastases, a study was performed in 45 liver metastases and 33 corresponding primary colorectal carcinomas in patients referred for liver surgery.

Ralf M. Zwacka, Yulong Zhang, Weihong Zhou, Jeff Halldorson, John F. Engelhardt – 30 December 2003 – For many inherited and acquired hepatic diseases, liver transplantation is the only possible therapeutic strategy. Ischemia/reperfusion (I/R) damage to donor tissue is thought to be one component that may play a role in the decline of posttransplant tissue function and ultimately rejection. The transcription factors, AP‐1 and nuclear factor κB (NF‐κB), play important roles in the acute cellular responses to tissue damage, as well as the inflammatory phase following I/R.

Paul Calès, Frédéric Oberti, Nary Veal, Joël Fort, Mehdi Kaassis, Frédéric Moal, Christophe Aubé, Eric Vuillenin, Christophe Pilette, Hervé Rifflet, Renaud Trouvé – 30 December 2003 – The aim of this study was to develop a technique that could serve as an index of portosystemic shunt (PSS) blood flow in portal hypertensive rats whose main shunt is the splenorenal shunt (SRS). The main hemodynamic measurements performed were: SRS blood flow by the transit‐time ultrasound (TTU) method, percentage of PSS, and regional blood flows by the microsphere method.

Kazuo Shimada, Javier Navarro, Douglas E. Goeger, Shamimunisa B. Mustafa, Paul H. Weigel, Steven A. Weinman – 30 December 2003 – The liver plays a major role in metabolism and elimination of leukotrienes (LT). It produces cysteinyl leukotrienes (cLT), and cLT have been implicated in hepatocellular toxicity in several models of lipopolysaccharide (LPS)‐associated liver injury.

K. Sandy Pang, Pi Jun Wang, Alfred Y. Chung, Allan W. Wolkoff – 30 December 2003 – Oatp1, the organic anion transport polypeptide, is an integral membrane protein cloned from rat liver that mediates the uptake of various organic anions such as bromosulfophthalein (BSP) and taurocholate (TCA). Recent studies by others revealed that the thrombin inhibitor, CRC 220, a modified dipeptide, was transported by oatp1. The present study was designed to examine whether another modified peptide, enalapril, an angiotensin‐converting enzyme inhibitor, was also a substrate.

Karine Mahéo, Fabrice Morel, Jocelyne Antras‐Ferry, Sophie Langouët, Fabienne Desmots, Laurent Corcos, André Guillouzo – 30 December 2003 – The effect of Escherichia coli lipopolysaccharide (LPS), a classic inducer of the acute‐phase response, has been analyzed on both constitutive and oltipraz (a chemoprotective agent)‐inducible messenger RNAs (mRNAs) and enzyme activities of major cytochromes P450 (CYPs) and glutathione transferases (rGSTs) in rat liver.

Jean‐Louis Payen, Jacques Izopet, Virginie Galindo‐Migeot, Valérie Lauwers‐Cances, Jean‐Pierre Zarski, Jean‐Marie Seigneurin, Elizabeth Dussaix, Jean‐Jacques Voigt, Janick Selves, Karl Barange, Jacqueline Puel, Jean‐Pierre Pascal, Le Groupe D'étude et De Traitement du Virus De L'hépatite C (Get.vhc) – 30 December 2003 – We studied the efficacy of three interferon alfa‐2b (IFN‐α2b) regimens for the retreatment of patients with chronic hepatitis C (CHC) with prior complete response followed by relapse.