Roger Williams, Julia Wendon – 1 July 1994 – The decision to undertake transplantation in a patient with fulminant liver failure requires consideration of many factors so that the physician may arrive at the most appropriate course of action. There are several definitions of fulminant liver failure used in current practice, all excluding patients with chronic liver disease. In the one most recently proposed, the terms hyperacute, acute and subacute liver failure are used to categorize groups of patients with different clinical appearances and progress.

Federico G. Villamil – 1 July 1994 – Background. The role of liver transplantation in patients positive for the hepatitis B surface antigen (HBsAg) is controversial because of the high rate of recurrent hepatitis B virus (HBV) infection. It has not been determined whether this risk is greater for certain patients and whether the administration of anti‐hepatitis B surface antigen (anti‐HBe) immune globulin is beneficial.

Marcel Blaise, Dominique Pateron, Jean‐Claude Trinchet, Serge Levacher, Michel Beaugrand, Jean‐Louis Pourriat – 1 July 1994 – This randomized prospective study was aimed at assessing the efficiency of a systemic antibiotic therapy for the prevention of bacterial infections in cirrhotic patients with gastrointestinal hemorrhage by ruptured esophageal varices. For 15 mo, all patients hospitalized with no infection on admission, were included in the study. Starting on admission day, patients in group A received ofloxacin (400 mg/day) for 10 days, first intravenously then orally.

Jean‐Pierre Benhamou – 1 July 1994

1 July 1994

Garwin K. Sing, Raymond Pace, Sharon Prior, Janet S. D. Scott, Paul Shield, Nicole Martin, Jeffrey Searle, Cameron Battersby, Lawrie W. Powell, W. Graham E. Cooksley – 1 July 1994 – We describe the establishment and characterization of a novel hepatoma cell line. This cell line, designated RBHF‐1, was established from a hepatocellular carcinoma of a 67‐yr‐old man with a history of genetic hemochromatosis. At this writing, the cells have been maintained in RPMI‐1640 tissue‐culture medium and fetal calf serum without any additional supplements for 30 mo.

Roy Calne – 1 July 1994

Paul D. Berk – 1 July 1994

Hiromitsu Hamaguchi, Yasuo Yamaguchi, Mataro Goto, Mikio Misumi, Naoya Hisama, Nobutomo Miyanari, Katsutaka Mori, Michio Ogawa – 1 July 1994 – The Eizai hyperbilirubinemic rat (EHBR) is a Sprague‐Dawley mutant rat with conjugated hyperbilirubinemia. Eizai hyperbilirubinemic rats have impaired canalicular excretory transport of organic anions, bile acid glucuronide and sulfate. Eizai hyperbilirubinemic rats, with and without a 68% partial hepatectomy, were treated by an intraportal injection of 1×107 wild‐type Sprague‐Dawley mutant rat hepatocytes.

Andras Divald, Edwin Simpser, Stanley E. Fisher, Peter I. Karl – 1 July 1994 – Bile salt uptake by hepatocytes is modulated in part by changes in intracellular cyclic AMP. We studied the effect of activation of protein kinase C on cyclic AMP‐mediated taurocholate uptake in isolated rat hepatocytes. Both dibutyryl cyclic AMP (2 × 10−6 mol/L) and glucagon (10−6 mol/L), which increase intracellular cyclic AMP, enhanced the initial uptake rate of taurocholate into hepatocytes, with maximal increases of 45% to 50% over the basal uptake rate.