Ruth E. Joplin, Gerald D. Johnson, John B. Matthews, John Hamburger, J. Gordon Lindsay, Stefan G. Hubscher, Alastair J. Strain, James M. Neuberger – 1 June 1994 – Previous studies in which quantitative immunofluorescence was used have shown that certain biliary epithelial cells in liver with primary biliary cirrhosis show increased levels of pyruvate dehydrogenase dihydrolipoamide acetyltransferase compared with controls.

Naoki Hiramatsu, Norio Hayashi, Kazuhiro Katayama, Kiyoshi Mochizuki, Yuko Kawanishi, Akinori Kasahara, Hideyuki Fusamoto, Takenobu Kamada – 1 June 1994 – Apoptosis is a type of cell death that occurs in acute or chronic hepatitis. It has been suggested to be mediated through Fas antigen. To evaluate the role of apoptosis on liver injury of chronic hepatitis C, we studied the expressions of Fas antigen and hepatitis C virus antigen (core antigen) immunohistochemically.

Takeshi Tanaka, Kyoko Tsukiyama‐Kohara, Kenjiro Yamaguchi, Shintaro Yagi, Satoshi Tanaka, Akira Hasegawa, Yohsuke Ohta, Nobu Hattori, Michinori Kohara – 1 June 1994 – Group I and II hepatitis C virus genotypes were determined by a newly developed serological genotyping assay. This assay detected antibodies against group‐specific recombinant proteins in the putative NS4 protein region (amino acid no. 1676–1760) by an enzyme‐linked immunosorbent assay.

J. Donald Ostrow – 1 June 1994

David T. Walden, Roger D. Soloway, Roger S. Crowther – 1 June 1994 – The aetiology of cancer of the extrahepatic bile duct is unknown. Gallstones have been proposed to be a risk factor on the basis of ecological and epidemiological evidence. As gallstones are formed in the gallbladder, the occurrence of extrahepatic bileduct cancer in patients after cholecystectomy is of interest.

Valeer J. Desmet, Michael Gerber, Jay H. Hoofnagle, Michael Manns, Peter J. Scheuer – 1 June 1994

Amin A. Nanji, Shuping Zhao, S. M. Hossein Sadrzadeh, David J. Waxman – 1 June 1994 – We evaluated the expression of interleukin‐1α, interleukin‐1β, tumor necrosis factor‐α and transforming growth factor‐β mRNAs in the intragastric‐feeding rat model of alcoholic liver disease. Rats were fed different diets for periods of 2 or 4 wk. Animals fed saturated fat and ethanol and the corn oil–dextrose control group had no liver injury, whereas animals fed corn oil and ethanol showed pathologic changes.

Mariano Ubeda, Marion M. Matzilevich, Noemí M. Atucha, Joaquín García‐Estañ, Tomás Quesada, Shiow‐Shih Tang, Julie R. Ingelfinger – 1 June 1994 – Activation of antinatriuretic systems such as the renin‐angiotensin system, is of major importance in the pathogenesis of sodium retention in cirrhosis. In this study, we studied the intrarenal renin‐angiotensin system by measuring renin and angiotensinogen mRNA expression in the kidney of rats subjected to long‐term bile duct ligation in a phase before the development of ascites, when sodium retention is already present.

Jianjun Li, Alan S. Rosman, Maria A. Leo, Yasuo Nagai, Charles S. Lieber – 1 June 1994 – One of the contributory factors to the development of cirrhosis is a decrease in collagenase activity, which may be related to levels of inhibitors such as serum tissue inhibitor of metalloproteinase.

1 June 1994