Endotoxin‐induced cytokine gene expression and excretion in the liver

Michael I. Luster, Dori R. Germolec, Takahiko Yoshida, Fujio Kayama, Morrow Thompson – 1 February 1994 – Peptide mediators, including tumor necrosis factor‐α, interleukin 1 and interleukin‐6, are associated with many chronic inflammatory diseases and septic shock. As such, considerable information has been collected by means of study of cytokine secretion from isolated cells or plasma cytokines during septic shock or inflammatory disorders.

Modulation of the asialoglycoprotein receptor in human hepatoma cells: Effect of glucose

Peretz Weiss, Gilbert Ashwell, Anatol G. Morell, Richard J. Stockert – 1 February 1994 – The hepatic receptor for asialoglycoproteins was found to be modulated by the glucose concentration in the medium of the human hepatoma cell line HepG2. The surface binding of asialoorosomucoid, a well‐documented ligand for this receptor, increased from 20 ng/mg of cellular protein to about 40 ng/mg as the glucose concentration was increased from 10 to 50 mg/dl.

Augmentation of portal blood flow improves function of human cirrhotic liver

Jorge E. Cardoso, Chantal Gautreau, Prema Raj Jeyaraj, Dariusz Patrzalek, Brigitte Cherruau, Michel Vaubourdolle, Claire Legendre, Tadeusz Wroblewski, Didier Houssin – 1 February 1994 – In cirrhotic livers, the intrahepatic resistance is increased and drug elimination and portal transhepatic flow are decreased. The aim of our work was to study the effect of a twofold increase in portal blood flow during 2 hr on the hemodynamic parameters, drug elimination and hepatic viability in eight isolated perfused human cirrhotic livers.

T‐cell response to structural and nonstructural hepatitis C virus antigens in persistent and self‐limited hepatitis C virus infections

Carlo Ferrari, Antonietta Valli, Lucia Galati, Amalia Penna, Patrizia Scaccaglia, Tiziana Giuberti, Claudia Schianchi, Gabriale Missale, Maria Grazia Marin, Franco Fiaccadori – 1 February 1994 – Twenty‐nine patients with chronic hepatitis C and 15 asymptomatic hepatitis C virus antibody–positive subjects who clinically recovered from hepatitis C virus infection were studied for their peripheral blood lymphomononuclear cell proliferative response to hepatitis C virus structural and nonstructural antigens (core, envelope, nonstructural 4 and nonstructural 5) expressed in yeast as superoxide d

…And the bands play on

Robert H. Schapiro – 1 February 1994 – Injection sclerotherapy of bleeding oesophageal varices is undoubtedly beneficial but it is associated with a substantial complication rate, and variceal rebleeding is common during the treatment period before variceal obliteration is achieved. We aimed to find out whether endoscopic variceal banding ligation is safer and more effective.

Reperfusion injury, antioxidants and hemodynamics during orthotopic liver transplantation

Helen F. Goode, Nigel R. Webster, Peter D. Howdle, Jack P. Leek, J. P. A. Lodge, Sammi A. Sadek, Barry E. Walker – 1 February 1994 – Endothelial injury occurs as a result of oxygen free radical production after ischemia and reperfusion of transplanted livers, causing hemodynamic disturbance. Patients with chronic liver disease generally have low levels of fat‐soluble vitamins, which have important antioxidant roles.

Vasoactive effect of endothelin‐1 on rat liver in vivo

Shigetoshi Okumura, Yoshiyuki Takei, Sunao Kawano, Kouichi Nagano, Eiji Masuda, Moritaka Goto, Shingo Tsuji, Tomoki Michida, Sheng‐Song Chen, Toru Kashiwagi, Hideyuki Fusamoto, Takenobu Kamada, Nobuhiro Sato – 1 January 1994 – The purpose of this study was to evaluate the role of endothelin‐1 in modulating hepatic microcirculation and liver damage. Rats were infused with endothelin‐1 at doses ranging from 30 to 1,000 pmol/kg over 1 min through an indwelling cannula placed in the portal vein. In control rats, saline solution was infused at the same rate.

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