Antonio Francavilla, Qihua Zeng, Lorenzo Polimeno, Brian I. Carr, Dantong Sun, Kendrick A. Porter, David H. van Thiel, Thomas E. Starzl – 1 January 1994 – Orthotopic liver transplantation was performed in 60 recipient rats weighing 200 to 250 gm. Sixty rats of the same strain were used as liver donors, 30 weighing 100 to 140 gm (small for size) and the other 30 weighing 200 to 250 gm (same size).
Nan Ni, James D. Yager – 1 January 1994 – Ethinyl estradiol is a weak complete carcinogen and potent tumor promoter. In vivo, ethinyl estradiol causes a rapid but transient increase in liver growth, whereas in cultured female hepatocytes it enhances DNA synthesis induced by epidermal growth factor and is thus classified as a comitogen.
Shushma Aggarwal, David Kramer, Howard Yonas, Walter Obrist, Yoogoo Kang, Maureen Martin, Raymond Policare – 1 January 1994 – The purpose of this retrospective study was to determine cerebral hemodynamic and metabolic changes in comatose patients with fulminant hepatic failure. Computerized tomography of the brain and cerebral blood flow measurements by the xenoncomputerized tomography scan or intravenous xenon‐133 methods were obtained in 33 patients with fulminant hepatic failure.
Ulrich Lauer, Ludwig Weiß, Martin Lipp, Peter Hans Hofschneider, Alexander S. Kekulé – 1 January 1994 – Integrated hepatitis B virus DNA cloned from hepatitis B virus‐associated hepatocellular carcinoma frequently contains 3′‐truncated middle surface genes (preS2/St), which were recently found to have a transcriptional transactivator function. Because preS2/St, among others, is able to transactivate the promoters of the cellular oncogenes c‐myc and c‐fos, it has been speculated that integrated preS2/St genes might contribute to hepatitis B virus‐associated liver carcinogenesis.
1 January 1994
Robert K. Ockner – 1 December 1993
Nelson Fausto – 1 December 1993 – In previous studies hepatocytes undergoing cell death by apoptosis but not normal hepatocytes in rat liver showed immunostaining for transforming growth factor β1 (TGF‐β1). Staining was much stronger with antibodies recognizing the pro‐region of TGF‐β1 than the mature peptide itself. Therefore we investigated the ability of both forms of TGF‐β1 to induce apoptosis in primary cultures of rat hepatocytes. Mature TGF‐β1 induced rounding up of the cells and fragmentation into multiple vesicles.
Jorge J. Gumucio – 1 December 1993
Ivor J. Benjamin – 1 December 1993
Kenji Fjuiwara, Sumiko Nagoshi, Akihiko Ohno, Keiichi Hirata, Yasuhiko Ohta, Satoshi Mochida, Tomoaki Tomiya, Kanji Higashio, Kiyoshi Kurokawa – 1 December 1993 – Human hepatocyte growth factor stimulates DNA synthesis by cultured rat hepatocytes. When human hepatocyte growth factor prepared from the culture medium of human embryonic lung fibroblasts was intravenously injected into normal rats and rats after 70% hepatectomy, it was detected in hepatocytes but not in nonparenchymal cells isolated 30 min after injection.