A Dual‐Filtration System for Single‐Cell Sequencing of Circulating Tumor Cells and Clusters in HCC

Vincent L. Chen, Qianhui Huang, Ramdane Harouaka, Yuheng Du, Anna S. Lok, Neehar D. Parikh, Lana X. Garmire, Max S. Wicha – 22 January 2022 – Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide. Identification and sequencing of circulating tumor (CT) cells and clusters may allow for noninvasive molecular characterization of HCC, which is an unmet need, as many patients with HCC do not undergo biopsy. We evaluated CT cells and clusters, collected using a dual‐filtration system in patients with HCC.

Features of Cirrhotic Cardiomyopathy Early in the Lives of Infants With Biliary Atresia Correlate With Outcomes Following Kasai Portoenterostomy

Jhavene Morrison, Eric Ferguson, Janet Figueroa, Saul J. Karpen – 20 January 2022 – Cirrhotic cardiomyopathy (CCM), detected during two‐dimensional echocardiography (2DE), is prevalent in patients with biliary atresia (BA) awaiting transplant. Whether CCM occurs early in the lives of infants with BA is unknown. The aim of this study was to explore the incidence and consequence of CCM in patients with BA, focusing on the earliest ages when 2DE was performed. A cohort of 78 patients with BA at a single center underwent 2DE (median age = 132 days) during the first year of life.

Risk Associations of Glycemic Burden and Obesity With Liver Cancer—A 10‐Year Analysis of 15,280 Patients With Type 2 Diabetes

Dandan Mao, Eric S.H. Lau, Hongjiang Wu, Aimin Yang, Baoqi Fan, Mai Shi, Claudia H.T. Tam, Elaine Chow, Alice P.S. Kong, Ronald C.W. Ma, Andrea Luk, Juliana C.N. Chan – 18 January 2022 – Liver is a major site for glucose metabolism. Patients with type 2 diabetes (T2D) and obesity have increased risk of liver cancer. We explored the association of glycemic burden (GB) and obesity with liver cancer in T2D in the prospective Hong Kong Diabetes Register (1995‐2019).

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