T cells: Friends and foes in NASH pathogenesis and hepatocarcinogenesis

Pierluigi Ramadori, Shing Kam, Mathias Heikenwalder – 11 January 2022 – In association with the pandemic spreading of obesity and metabolic syndrome, the prevalence of NAFLD‐related HCC is increasing almost exponentially. In recent years, many of the underlining multifactorial causes of NAFLD have been identified, and the cellular mechanisms sustaining disease development have been dissected up to the single‐cell level.

Risk Factors for Posttransplantation Mortality in Recipients With Grade 3 Acute‐on‐Chronic Liver Failure: Analysis of a North American Consortium

Vinay Sundaram, Sarvanand Patel, Kirti Shetty, Christina C. Lindenmeyer, Robert S. Rahimi, Gianina Flocco, Atef Al‐Attar, Constantine J. Karvellas, Suryanarayana Challa, Harapriya Maddur, Janice H. Jou, Michael Kriss, Lance L. Stein, Alex H. Xiao, Ross H. Vyhmeister, Ellen W. Green, Braidie Campbell, William Cranford, Nadim Mahmud, Brett E.

LiverLearning®: 2022 Webinar: HBV DNA Integration: Mechanisms, Pathogenesis and Clinical Relevance in Liver Disease Progression and Functional Cure

The goal of this webinar is to review mechanisms of HBV DNA integration in the context of potential clinical relevance including HCC, clinical monitoring, treatment and emerging therapeutics towards a functional cure. Some questions to be explored re: HBV DNA integration in this webinar: What is it? How/when does it happen? What is its potential impact in liver disease pathogenesis and clinical outcome (e.g. HCC)? What are potential impact of HBV DNA integration on timing of treatment initiation, clinical monitoring and novel therapeutic development?Stefan F.

Dual Targeting of Angipoietin‐1 and von Willebrand Factor by microRNA‐671‐5p Attenuates Liver Angiogenesis and Fibrosis

Le Yang, Wenhui Yue, Hang Zhang, Zhi Zhang, Renmin Xue, Chengbin Dong, Fuquan Liu, Na Chang, Lin Yang, Liying Li – 10 January 2022 – Angipoietin‐1 (Angpt1) and von Willebrand factor (VWF) are two important angiogenic molecules that can drive pathologic angiogenesis and progression of liver fibrosis in our previous study. MicroRNAs (miRs) participate in a variety of physiological and pathological processes, including angiogenesis. However, the critical miRs targeting Angpt1 or VWF and potential molecular mechanism underlying liver fibrosis–associated angiogenesis is not clear yet.

Hepatocyte TGF‐β Signaling Inhibiting WAT Browning to Promote NAFLD and Obesity Is Associated With Let‐7b‐5p

Jinfang Zhao, Lilin Hu, Wenfang Gui, Li Xiao, Weijun Wang, Jing Xia, Huiqian Fan, Zhonglin Li, Qingjing Zhu, Xiaohua Hou, Huikuan Chu, Ekihiro Seki, Ling Yang – 10 January 2022 – Transforming growth factor beta (TGF‐β) signaling in hepatocytes promotes steatosis and body weight gain. However, processes that TGF‐β signaling in hepatocytes promote pathological body weight gain in nonalcoholic fatty liver disease (NAFLD) are incompletely understood.

Outcomes of Simultaneous Liver‐Kidney Transplantation Using Kidneys of Deceased Donors With Acute Kidney Injury

Ramesh K. Batra, Venkatesh K. Ariyamuthu, Malcolm P. MacConmara, Gaurav Gupta, Ahmet B. Gungor, Bekir Tanriover – 9 January 2022 – Outcomes from simultaneous liver‐kidney transplantation (SLKT) when using kidneys from donors with acute kidney injury (AKI) have not been studied. We studied 5344 SLKTs between May 1, 2007, and December 31, 2019, by using Organ Procurement and Transplantation Network registry data supplemented with United Network for Organ Sharing–DonorNet data.

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