Ross A. McKinnon, Pauline de la M. Hall, Linda C. Quattrochi, Robert H. Tukey, Michael E. McManus – 1 November 1991 – To better characterize the precise cellular distribution of CYP1A gene products in man, we have undertaken Northern‐blot and in situ hybridization analyses of CYP1A expression in human liver. Using riboprobes transcribed from both CYP1A1 and CYP1A2 complementary DNAs to probe a series of Northern blots of 23 human liver messenger RNA samples, CYP1A1 expression was demonstrated in 11 samples and CYP1A2 expression was evident in 22 samples.

António José Lanca, Yedy Israel – 1 November 1991 – Most histochemical methods for the detection of an enzymatic activity are preceded by tissue fixation with chemical agents that partially inactivate the enzymes. It is well known that substrates exert a marked protection against fixative‐induced inactivation.

Jorge J. Gumucio, Laurence M. Blendis – 1 November 1991 – We investigated the role of early portal hypotensive pharmacotherapy in preventing the development of portal‐systemic shunting in a portal hypertensive model of chronic murine schistosomiasis induced by infecting C3H mice with 60 cercariae of Schistosoma mansoni. Propranolol was administered in drinking water to 20 animals for a period of 6 wk at a dose of 10 mg · kg−1 d−1, starting at 5 wk of schistosomal infection. 32 age‐matched mice with chronic schistosomal infection served as controls.

Douglas M. Heuman, W. Michael Pandak, Philip B. Hylemon, Z. Reno Vlahcevic – 1 November 1991 – Intraduodenal infusion of hydrophobic bile salts to bile‐fistula rats leads within hours to severe hepatocellular necrosis and cholestasis; simultaneous administration of conjugates of ursodeoxycholate, either intraduodenally or intravenously, reduces or prevents liver injury.

Raymond S. Koff – 1 November 1991

Karen Peterson – 1 November 1991

Luisa Benvegnù, Daniela Cavalletto, Maria Grazia Ruvoletto, Alfredo Alberti – 1 November 1991

Jean‐Yves Scoazec, Gérard Feldmann – 1 November 1991 – Hepatic sinusoids are highly specialized capillary vessels characterized by the presence of resident macrophages adhering to the endothelial lining. Although it is likely that sinusoidal endothelial cells have specific adaptations, little is known about the roles that they actually play in vivo.

Dirk de Craemer, Ingrid Kerckaert, Frank Roels – 1 November 1991 – The peroxisomes in the liver of four patients with alcoholic hepatitis and in six patients with druginduced hepatitis are compared to eight control livers by catalase cytochemistry and morphometry. A decrease of catalase activity is observed in alcoholic, amitriptyline, aprindine, clomipramine and methimazole hepatitis. Peroxisomes with a heterogeneous distribution of the catalase reaction product are found in most hepatitis livers.

Marco Bertolotti, Nicola Abate, Paola Loria, Michele Dilengite, Francesca Carubbi, Adriano Pinetti, Antonia Dlgrisolo, Nicola Carulli – 1 November 1991 – The rates of cholesterol 7α‐hydroxylation (the first and rate‐limiting step of bile acid synthesis from cholesterol) were evaluated in vivo in patients administered bile acids with different structural properties, cholestyramine or simvastatin, a competitive inhibitor of 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase.